Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel test method to replace animal testing

16.08.2016

Testing the impact of chemo toxicity on the human development without having to resort to animal testing: To get closer to this goal, the University of Veterinary Medicine Hannover, Foundation (TiHo) and the Laser Zentrum Hannover e.V. (LZH) are developing a new in-situ test method to examine the hazardous potential of chemical substances.

„In Germany, animal protection is particularly important and anchored in the constitution. Humans may not cause animals unnecessary pain, suffering or injury”, explains the German Federal Ministry of Education and Research (BMBF). In order to comply with and to extend the protection of animals, a funding program was initiated to support the research for alternatives to animal testing.


Migrating pioneer neurons under the phase contrast microscope, selectively stained by a fluorescence dye (red).

TiHo

New method works without animal testing

Within the course of this program, the TiHo and the LZH are now developing a method to analyze, for example, the neurotoxic properties of industrial chemicals or pesticides. As a result, it shall be possible for the first time to perform these analyses without animal testing.

For this alternative testing system, the TiHo develops a biological analysis method based on an insect embryo that will then be combined with a 3D imaging method of the the LZH. Thereby, disturbances in pioneer neurons caused by chemicals are detected. In these neurons, the growth of the nerve fibers towards the central nervous system is changed. In their fixed developmental patterns, defects in the growth process of neurons, the cell migration and the cell death can be seen. The precise imaging method ensures the detection required for the analysis.

The new methodology allows for high-throughput test series. Applications fields are both fundamental research as well as the pre-regulatory area for the identification of toxicologically relevant substances. Thus, animal tests in the run-up to the approval of chemicals could be replaced.

Avoiding damages in the prenatal and early childhood period

As the new method shall be used for test series to detect developmental neuro toxicity, it is also possible to investigate if individual chemicals or the combination of different substances is potentially harmful for the prenatal or early childhood development. Here, it is tested if the contact can lead to functional limitations or deformations of individual body parts or organs of the child.

Further possible applications

Moreover, the test method can be used for drug development, too. In this field it could complement or, in the long term, even replace ethically questionable and costly animal test series.

The project “Pionieraxon“ (funding code 031L0062B) is supported by the German Federal Ministry of Education and Research (BMBF) within the scope of the announcement “alternatives to animal testing”.

Dr. Nadine Tinne | idw - Informationsdienst Wissenschaft
Further information:
http://www.lzh.de/

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>