Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel test method to replace animal testing

16.08.2016

Testing the impact of chemo toxicity on the human development without having to resort to animal testing: To get closer to this goal, the University of Veterinary Medicine Hannover, Foundation (TiHo) and the Laser Zentrum Hannover e.V. (LZH) are developing a new in-situ test method to examine the hazardous potential of chemical substances.

„In Germany, animal protection is particularly important and anchored in the constitution. Humans may not cause animals unnecessary pain, suffering or injury”, explains the German Federal Ministry of Education and Research (BMBF). In order to comply with and to extend the protection of animals, a funding program was initiated to support the research for alternatives to animal testing.


Migrating pioneer neurons under the phase contrast microscope, selectively stained by a fluorescence dye (red).

TiHo

New method works without animal testing

Within the course of this program, the TiHo and the LZH are now developing a method to analyze, for example, the neurotoxic properties of industrial chemicals or pesticides. As a result, it shall be possible for the first time to perform these analyses without animal testing.

For this alternative testing system, the TiHo develops a biological analysis method based on an insect embryo that will then be combined with a 3D imaging method of the the LZH. Thereby, disturbances in pioneer neurons caused by chemicals are detected. In these neurons, the growth of the nerve fibers towards the central nervous system is changed. In their fixed developmental patterns, defects in the growth process of neurons, the cell migration and the cell death can be seen. The precise imaging method ensures the detection required for the analysis.

The new methodology allows for high-throughput test series. Applications fields are both fundamental research as well as the pre-regulatory area for the identification of toxicologically relevant substances. Thus, animal tests in the run-up to the approval of chemicals could be replaced.

Avoiding damages in the prenatal and early childhood period

As the new method shall be used for test series to detect developmental neuro toxicity, it is also possible to investigate if individual chemicals or the combination of different substances is potentially harmful for the prenatal or early childhood development. Here, it is tested if the contact can lead to functional limitations or deformations of individual body parts or organs of the child.

Further possible applications

Moreover, the test method can be used for drug development, too. In this field it could complement or, in the long term, even replace ethically questionable and costly animal test series.

The project “Pionieraxon“ (funding code 031L0062B) is supported by the German Federal Ministry of Education and Research (BMBF) within the scope of the announcement “alternatives to animal testing”.

Dr. Nadine Tinne | idw - Informationsdienst Wissenschaft
Further information:
http://www.lzh.de/

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>