Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel form of experience-dependent plasticity in the adult brain revealed

06.02.2015

Research by a team of scientists from Cologne, Munich and Mainz have shown an unprecedented degree of connectivity reorganization in newly-generated hippocampal neurons in response to experience, suggesting their direct contribution to process complex information in the adult brain.

The hippocampus is an anatomical area of the brain classically involved in memory formation and modulation of emotional behavior. This is also one of the very few regions in the adult brain where resident neural stem cells generate new neurons life-long, thus providing the hippocampal circuitry with an almost unique renewal mechanism important for information processing and mood regulation.

In response to experience and voluntary exercise, the amount of new neurons that incorporate into the hippocampus increases. Now, Dr. Matteo Bergami from CECAD Cologne together with scientists from the LMU Munich and the University Medical Center of the Johannes Gutenberg University in Mainz have joined their efforts to investigate whether experience, rather than merely promoting neurogenesis, also modifies the connectivity of new neurons.

The scientists successfully showed that the pattern of connectivity of new neurons, namely the number and types of inputs received by each new neuron, is not prefigured in the adult brain but can be significantly altered in response to complex environmental conditions. In fact, following environmental enrichment (EE) the innervation by both local hippocampal interneurons and long distance projection cortical neurons was substantially increased.

However, while the inhibitory inputs were largely transient, cortical innervation remained elevated even after ending the exposure to EE. These findings reveal that exposure to complex environmental stimuli as well as their deprivation regulates the way new neurons become incorporated into the preexisting circuitry and thus, their engagement into hippocampal-dependent tasks.

These findings significantly contribute to deepen our understanding of how the brain responds to experience, and how external stimuli are translated into stable changes of neuronal connectivity.

Their results will not only help deciphering how complex learning processes modify the brain´s plasticity, but may also create an experimental basis for investigating the maladaptive changes in brain connectivity associated with neurological and neuropsychiatric disorders such as epilepsy, depression, anxiety, and posttraumatic stress.

The research group’s results represent a crucial step towards realizing the broader vision of CECAD at the University of Cologne, namely to understand the molecular and cellular basis of aging-associated diseases as a mean to develop new effective therapeutic strategies.

Contact:
Dr. Matteo Bergami
CECAD Excellence Cluster at the University of Cologne
Telephone +49 221 478-84250
matteo.bergami@uk-koeln.de

Astrid Bergmeister MBA
Head CECAD PR & Marketing
Telephone + 49 (0) 221-478 84043
astrid.bergmeister@uk-koeln.de

Weitere Informationen:

http://www.cecad.uni-koeln.de

Astrid Bergmeister | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>