Shrout, assistant professor of civil engineering and geological sciences and a member of the Eck Institute for Global Health, has been studying the surface motility of bacteria since 2004.
In 2008, UCLA researcher Gerard Wong suggested that an undergraduate bioengineering senior design group that he was advising track the bacterium Shrout was studying. After some interesting patterns were observed initially, Shrout collected more data to send to Wong's group and they refined their analysis to allow for identification of very specific patterns by the bacteria, including "walking."
In a paper appearing in today's edition of the journal Science, Shrout, Wong and other researchers report on their findings.
"The significance of the work is that we show bacteria are capable of 'standing up' and moving while vertical," Shrout said. "The analysis methodology developed by Gerard's group made this observation possible. They developed a computer program to analyze time-lapse data series, just like those showing plant development that you watched on PBS as a kid, of bacterial motion on surfaces. By tracking thousands of bacteria for minutes to hours, the stand-up walking pattern was observed and verified to occur with some frequency."
Apart from being an extraordinary insight into the behavior of bacteria, the findings have important biomedical implications.
"The significance to medicine is that the bacterium we study, Pseudomonas aeruginosa, causes lung, skin, eye and gastrointestinal infections," Shrout said. "Such infections are, unfortunately, the leading cause of death for individuals with Cystic Fibrosis. As we learn more about how Pseudomonas aeruginosa colonizes surfaces, perhaps we can develop better methods to treat these infections."
Dominick Motto, who was graduated from Notre Dame in May with a degree in biology, worked with Shrout on the on the experiments used in the research analysis.
"It has been great to work with Gerard's group on this project because we have meshed multiple scientific approaches for this discovery," Shrout said. "It also has been rewarding to integrate each level of researcher into this project: undergrad, graduate student, post-doc and professor. The ability to conduct cutting edge science while training future scientists is very rewarding."
Joshua Shrout | EurekAlert!
The birth of a new protein
20.10.2017 | University of Arizona
Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research