Shrout, assistant professor of civil engineering and geological sciences and a member of the Eck Institute for Global Health, has been studying the surface motility of bacteria since 2004.
In 2008, UCLA researcher Gerard Wong suggested that an undergraduate bioengineering senior design group that he was advising track the bacterium Shrout was studying. After some interesting patterns were observed initially, Shrout collected more data to send to Wong's group and they refined their analysis to allow for identification of very specific patterns by the bacteria, including "walking."
In a paper appearing in today's edition of the journal Science, Shrout, Wong and other researchers report on their findings.
"The significance of the work is that we show bacteria are capable of 'standing up' and moving while vertical," Shrout said. "The analysis methodology developed by Gerard's group made this observation possible. They developed a computer program to analyze time-lapse data series, just like those showing plant development that you watched on PBS as a kid, of bacterial motion on surfaces. By tracking thousands of bacteria for minutes to hours, the stand-up walking pattern was observed and verified to occur with some frequency."
Apart from being an extraordinary insight into the behavior of bacteria, the findings have important biomedical implications.
"The significance to medicine is that the bacterium we study, Pseudomonas aeruginosa, causes lung, skin, eye and gastrointestinal infections," Shrout said. "Such infections are, unfortunately, the leading cause of death for individuals with Cystic Fibrosis. As we learn more about how Pseudomonas aeruginosa colonizes surfaces, perhaps we can develop better methods to treat these infections."
Dominick Motto, who was graduated from Notre Dame in May with a degree in biology, worked with Shrout on the on the experiments used in the research analysis.
"It has been great to work with Gerard's group on this project because we have meshed multiple scientific approaches for this discovery," Shrout said. "It also has been rewarding to integrate each level of researcher into this project: undergrad, graduate student, post-doc and professor. The ability to conduct cutting edge science while training future scientists is very rewarding."
Joshua Shrout | EurekAlert!
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy