Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study finds strong link between obesity and 'carb breakdown' gene

31.03.2014

Researchers at King's College London and Imperial College London have discovered that people with fewer copies of a gene coding for a carb-digesting enzyme may be at higher risk of obesity.

The findings, published in Nature Genetics, suggest that dietary advice may need to be more tailored to an individual's digestive system, based on whether they have the genetic predisposition and necessary enzymes to digest different foods.

Salivary amylase plays a significant role in breaking down carbohydrates in the mouth at the start of the digestion process. The new study suggests that people with fewer copies of the AMY1 gene have lower levels of this enzyme and therefore will have more difficulty breaking down carbohydrates than those with more copies.

Previous research has found a genetic link between obesity and food behaviours and appetite, but the new discovery highlights a novel genetic link between metabolism and obesity. It suggests that people's bodies may react differently to the same type and amount of food, leading to weight gain in some and not in others. The effect of the genetic difference found in the latest study appears much stronger link than any of those found before.

Researchers first measured gene expression patterns in 149 Swedish families with differences in the levels of obesity and found unusual patterns around two amylase genes (AMY1 and AMY2), which code for salivary and pancreatic amylase. This was suggestive of a variation in copy numbers relating directly to obesity.

The finding was replicated strongly in 972 twins from TwinsUK, the biggest UK adult twin registry, which found a similar pattern of expression. The researchers then estimated the precise copy numbers of the amylase gene in the DNA of a further 481 Swedish subjects, 1,479 subjects from TwinsUK and 2,137 subjects from the DESIR project.

The collaborative team found that the number of copies of the AMY1 gene (salivary amylase) was consistently linked to obesity. Further replication in French and Chinese patients with and without obesity showed the same patterns.

A lower estimated AMY1 copy-number showed a significantly increased risk of obesity in all samples and this translated to an approximate eight-fold difference in the risk of obesity between those subjects with the highest number of copies of the gene and those with the lowest.

Standard Genome wide mapping methods (GWAS) had missed this strong association as the area is technically hard to map. This variation in copy numbers, also known as 'copy number variants' (CNV) has been underestimated as a genetic cause of disease, but the link between CNV in the amylase gene and obesity provides an indication that other major diseases may be influenced by similar mechanisms.

Professor Tim Spector, Head of the Department of Twin Research and Genetic Epidemiology at King's College London and joint lead investigator said: "These findings are very exciting. While studies to date have mainly found small effect genes that alter eating behaviour, we discovered how the digestive 'tools' in your metabolism vary between people – and the genes coding for these – can have a large influence on your weight.

"The next step is to find out more about the activity of this digestive enzyme, and whether this might prove a useful biomarker or target for the treatment of obesity.

"In the future, a simple blood or saliva test might be used to measure levels of key enzymes such as amylase in the body and therefore shape dietary advice for both overweight and underweight people. Treatments are a long way away but this is an important step in realising that all of us digest and metabolise food differently – and we can move away from 'one-size fits all diets' to more personalised approaches."

Hannah Pluthero | EurekAlert!
Further information:
http://www.kcl.ac.uk

Further reports about: CNV amylase breakdown copies difference enzyme enzymes findings genes levels metabolism subjects weight

More articles from Life Sciences:

nachricht New technology helps ID aggressive early breast cancer
01.07.2016 | University of Michigan Health System

nachricht In times of great famine, microalgae digest themselves
01.07.2016 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Mainz-based physicists find missing link between glass formation and crystallization

Densified regions with drastically reduced internal motion either act as crystal precursors or cluster and frustrate all further dynamics

Glasses are neither fluids nor crystals. They are amorphous solids and one of the big puzzles in condensed matter physics. For decades, the question of how...

Im Focus: Thousands on one chip: New Method to study Proteins

Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. Applying this new method, an international team of researchers with leading participation of the Technical University of Munich (TUM) was able to identify hundreds of previously unknown interactions among proteins.

The human genome and those of most common crops have been decoded for many years. Soon it will be possible to sequence your personal genome for less than 1000...

Im Focus: Optical lenses, hardly larger than a human hair

3D printing enables the smalles complex micro-objectives

3D printing revolutionized the manufacturing of complex shapes in the last few years. Using additive depositing of materials, where individual dots or lines...

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Quantum technologies to revolutionise 21st century - Nobel Laureates discuss at Lindau

30.06.2016 | Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

 
Latest News

Mainz-based physicists find missing link between glass formation and crystallization

01.07.2016 | Physics and Astronomy

Scientists observe first signs of healing in the Antarctic ozone layer

01.07.2016 | Earth Sciences

MRI technique induces strong, enduring visual association

01.07.2016 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>