The antibiotic-resistant bacterium Acinetobacter baumanii often causes fatal nosocomial infections.
A research unit, approved by the German Research Foundation, under the leadership of researchers based in Frankfurt, has made it their goal to throw light on the infection process and the adaptation mechanisms of the germ. The fundamental insights gained by the research unit will pave the road for the clinical management of this germ.
Multi-drug resistant bacteria have increased dramatically in hospitals in recent years and present immense challenges to staff and patients, often with fatal results. In addition to well-known bacteria such as Staphylococcus aureus, new pathogens have come to light in the past few years. One of these is the Gram negative Acinetobacter baumannii.
The German Research Foundation has now approved a new Research Unit, under the leadership of researchers based in Frankfurt, that will unravel the molecular basis for the dramatic increase in multi-drug resistant A. baumannii strains.
A. baumannii has become a common and excellently adapted nosocomial pathogen in developed countries. It causes 5% to 10% of nosocomial pneumonias and 2% to 10% of all infections in the intensive care wards in European clinics. The increase in antibiotic resistance is alarming. The germ belong to the group of six "ESKAPE" organisms that evade antibiotic treatment. Therefore, infections with A. baumannii are frequently fatal.
Several institutes of the Goethe University are involved in the research group 2251 "Adaptation and persistence of Acinetobacter baumannii": the Department of Molecular Microbiology & Bioenergetics, the Institute of Medical Microbiology and Hygiene, the Institute for Cell Biology and Neuroscience, and the Institute for Biochemistry.
The Universities of Cologne and Regenburg, as well as the Robert Koch Institute, are additional collaborators. The researchers will study the biology, infection process and the basis for multi-drug resistance of A. baumannii using a highly interdisciplinary approach. The objective is to determine how it has adapted so well to the hospital environment and what the multi-drug resistance is based on. The answers to these questions will facilitate the treatment related to this dramatically increasing nosocomial pathogen.
Information: Prof. Volker Müller, Coordinator of the Research Unit 2251, Molecular Microbiology and Bioenergetics, Riedberg Campus, Tel: (069)798-29507; firstname.lastname@example.org., http://www.bio.uni-frankfurt.de/51172482
The Goethe University is an institution with particularly strong research capabilities based in the European financial metropolis of Frankfurt. It celebrates its 100th year of existence in 2014. The university was founded in 1914 through private means from liberally orientated citizens of Frankfurt and has devoted itself to fulfilling its motto "Science for the Society" in its research and teaching activity right up to the present day. Many of the founding donors were of Jewish origin. During the last 100 years, the pioneering services offered by the Goethe University have impacted the fields of social, societal and economic sciences, chemistry, quantum physics, neurological research and labour law. On January 1st, 2008, it achieved an exceptional degree of independence as it returned to its historical roots as a privately funded university. Today it is one of the ten universities that are most successful in obtaining external research funding and one of the three largest universities in Germany with centres of excellence in medicine, life sciences and humanities.
Publisher: The President of Goethe-University Frankfurt/Main. Editor: Dr. Anke Sauter, Marketing und Communication, Grüneburgplatz 1, 60323 Frankfurt am Main, Phone 0049(0)69-798-12478, 0049(0)69-798-28530
Dr. Anne Hardy-Vennen | idw - Informationsdienst Wissenschaft
New Model of T Cell Activation
27.05.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau
Fungi – a promising source of chemical diversity
27.05.2016 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut (HKI)
A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.
The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene
In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
27.05.2016 | Awards Funding
27.05.2016 | Life Sciences
27.05.2016 | Life Sciences