Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New EU project designed to link diagnosis and treatment of diseases over the long term

20.11.2015

Joint research project aims at the improvement of companion diagnostics and therapy of tumor diseases

An international team from four EU countries plans to use an innovative concept to improve the use of companion diagnostics in disease and develop new approaches to therapy in the long term. The idea is to combine the use of nanomedicines and short half-life radionuclides for imaging purposes in the living organism.


Enhanced contrast will significantly improve the accuracy of cancer diagnosis.

Ill./©: Click It Consortium

First the nanomedicines, in the form of synthetic nanoparticles or antibodies, are introduced in the body where they actively or passively accumulate in certain organisms or cells. The second stage involves the delivery of a radioactive substance.

Where the substance encounters the nanoparticles, a rapid chemical reaction occurs and the two bind together, while the remainder of the substance is eliminated from the body. With the help of an imaging technique, it is now possible to precisely pinpoint where the nanoparticles are located, to what extent they have accumulated at the target site, and what effect they are having on the disease pathology. The EU is funding the project to the tune of EUR 6 million over the next five years.

Participating are physicians and clinicians from Copenhagen, chemists at TU Wien, and Johannes Gutenberg University Mainz (JGU), together with commercial partners from Austria and the Netherlands. The project was launched with the clear ambition of transferring the technology into clinical practice.

The research consortium aims at improving companion diagnostics and, at the same time, reducing exposure of patients to radioactivity to an absolute minimum. Companion diagnostics are tools in the form of medical devices that are used to assess medications in advance and can help determine which patients are likely to benefit from a treatment. For example, it is already possible to treat HER2-positive breast cancer using antibody therapy with relatively high therapeutic success rates.

However, only about 20 percent of all breast tumors are HER2-positive and the treatment is very expensive. It is thus advisable to first establish whether a patient is HER2-positive before initiating the therapy. Companion diagnostics can thus be used to determine if an individual patient is suitable for a specific form of therapy and would benefit from it or whether an alternative form of treatment should be preferred. In addition, the outcome of the therapy can be subsequently visualized. It is thus possible that the project may also contribute towards the future development of medicines that are more effective, more rapid, and less expensive.

"The system we are proposing would allow us to do far more than simply determine exactly where the nanoparticles are in the body," explained polymer chemist Dr. Matthias Barz of the Institute of Organic Chemistry at Mainz University, who is involved in the project. "There is the imaging factor that will allow us to see where our nanoparticles with their specific function are located in the body. And, eventually, it should at some point be possible to use our approach in radiotherapy – making it truly unique."

The two cooperation partners in Mainz, Dr. Matthias Barz and Professor Rudolf Zentel, are contributing their expertise in the production of microparticles of nanoparticles with specific functions. The European Union is making EUR 300,000 available over the next three years to fund their project.


Further information:
Dr. Matthias Barz
Institute of Organic Chemistry
Johannes Gutenberg University Mainz (JGU)
55099 Mainz, GERMANY
phone: +49 6131 39-26256
fax: +49 6131 39-24778
e-mail: barz@uni-mainz.de
http://www.ak-zentel.chemie.uni-mainz.de/1012.php
http://www.ak-zentel.chemie.uni-mainz.de/eng/index.php

Weitere Informationen:

http://www.uni-mainz.de/presse/19912_ENG_HTML.php - press release ;
http://www.ak-zentel.chemie.uni-mainz.de/eng/index.php - Zentel Group at the Institute of Organic Chemistry at Johannes Gutenberg University Mainz

Petra Giegerich | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>