We now begin to understand how signalling proteins recognize and transport to certain areas of the cell and get a more clear insight on the mechanism of major cellular processes such as cell signalling and growth. This valuable knowledge could be used in the future to understand and cure disease such as depression and Alzheimer's explains Associate Professor Dimitrios Stamou, Nano-Science Center and Department of Neuroscience and Pharmacology, who led the work.
Cells depend critically on their ability to selectively, transport and isolate proteins in specific areas. Earlier ideas that proposed proteins to move around in the cell by recognizing nanoscale patches in their surrounding membrane, also called lipid rafts, are currently under intense debate. However researchers from Nano-Science Center found a new unsuspected mechanism based on the shape of the membrane and just had their results published in the prominent scientific journal Nature Chemical Biology.Attractive curves on the nanoscale
- We were very surprised that it is the number of cracks in the membrane that determines how many proteins are bound. Up until now researchers in the field thought that the crucial element was the proteins ability and "desire" to bind to the membrane, also called the affinity. Our data speaks against that, explains Nikos Hatzakis, Nano-Science Center and Department of Chemistry.The model is general
- The moment we understood that the most critical parameter in our observations was membrane-shape we immediately thought that maybe we found a general mechanism that would apply to many other types of proteins apart from the ones we were studying. So we tested G proteins that are important signalling proteins attached to the membrane in a different way, using a lipid anchor. Our data confirmed that the model was indeed general, explains Vikram Bhatia, Nano-Science Center and Department of Nanoscience and Pharmacology.
- Unravelling the overarching importance of membrane-shape for the localization of literally hundreds of important signalling proteins will prove critical to our understanding of a plethora of biological process many of which are directly linked to important diseases, emphasises Associate Professor Dimitrios Stamou.
Dimitrios Stamou | EurekAlert!
BigH1 -- The key histone for male fertility
14.12.2017 | Institute for Research in Biomedicine (IRB Barcelona)
Guardians of the Gate
14.12.2017 | Max-Planck-Institut für Biochemie
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
14.12.2017 | Health and Medicine
14.12.2017 | Physics and Astronomy
14.12.2017 | Life Sciences