Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nanoparticles added to platelets double internal injury survival rate

21.08.2012
Results of early lab study hold promise for trauma cases

Nanoparticles tailored to latch onto blood platelets rapidly create healthy clots and nearly double the survival rate in the vital first hour after injury, new research shows.

"We knew an injection of these nanoparticles stopped bleeding faster, but now we know the bleeding is stopped in time to increase survival following trauma," said Erin Lavik, a professor of biomedical engineering at Case Western Reserve University and leader of the effort.

The researchers are developing synthetic platelets that first responders and battlefield medics could carry with them to stabilize car crash or roadside bomb victims. An injection could slow or halt internal bleeding until the victim reaches a hospital and receives blood transfusions and surgery.

Lavik spoke about the latest breakthroughs in her research today at the American Chemical Society's annual meeting in Philadelphia.

Lavik and her colleagues began focusing on synthetic platelets after learning the military has no equivalent of a tourniquet, pressure dressing or other easily transportable technology to stem bleeding from internal injuries.

But as they explored possible applications, they recognized that the approach is widely needed beyond military conflict. Traumatic injury is the leading cause of death for people age 4 to 44, often overwhelming the body's natural blood-clotting process.

The platelet-like nanoparticles are made of biodegradable polymers used in devices already approved by the Food & Drug Administration for use in humans. They're designed to hone in on injuries after injection. Natural platelets, activated by injury, emit chemicals that bind natural platelets and the additional synthetics into a larger clot faster than natural platelets alone.

Tested on a lethal liver injury model in lab rats, the one-hour survival rate of the models injected with the nanoparticles was 80 percent. For control groups treated with saline alone the survival rate fell to 47 percent, while control groups receiving scrambled nanoparticles totaled just 40 percent. Among the three, the models treated with the platelet-like nanoparticles exhibited the least blood loss.

The researchers also found that the hybrid clots were as firm as natural clots. In additional testing, they found no complications following administration of the nanoparticles.

Earlier tests showed these synthetic platelets can cut bleeding time by as much as half and that, a week later, the rats showed no ill effects from the materials

The researchers include graduate students Andrew J. Shoffstall, Lydia M. Everhart and Margaret M. Lashof-Sullivan; research assistants Kristyn T. Atkins and Rebecca E. Groynom; undergraduate student Matt E. Varley; and administrative assistant Blaine Martin-Dow, all of Case Western Reserve. They are teamed with Robert S. Butler, of the Department of Quantitative Health Services at the Cleveland Clinic, and Jeffrey S. Ustin, assistant professor, Case Western Reserve University School of Medicine and member of the Department of General Surgery at the Cleveland Clinic.

They are continuing to test the platelets with other models of injury, working toward the best design and dosage for human use.

Kevin Mayhood | EurekAlert!
Further information:
http://www.case.edu

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>