Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mystery of the Missing Breast Cancer Genes

09.05.2012
Researchers from the University of Adelaide are hoping to better understand why the mutated genes for breast and ovarian cancer are not passed on more frequently from one generation of women to the next.

That's despite a documented link between breast cancer genes and increased fertility in women.

Dr Jack da Silva from the University's School of Molecular & Biomedical Science says that because women who carry breast cancer genes are more fertile, in theory they have a greater chance of passing these genes on to future generations.

"A recent study in the United States found that mutations in the breast cancer genes BRCA1 and BRCA2 were directly linked with a 50% increase in the fertility of women, which is a huge number," Dr da Silva says.

"With such an increased fertility rate, you would expect to see a high frequency of these cancer-causing genes in modern populations, but in fact that is not the case - the frequencies are relatively low."

In a paper being published today in the Proceedings of the Royal Society B, he argues that the so-called "grandmother effect" may in part be the reason behind this phenomenon.

"In an earlier study, researchers found that post-menopausal women create a 'grandmother effect' - that is, the longer they live, the more they are able to support their daughters and their grandchildren, thereby creating an environment in which more grandchildren are born.

"The reverse of this is that women who die earlier - such as from breast or ovarian cancer, which are usually post-menopausal - will no longer be able to support their daughters and grandchildren. This has the effect of limiting the number of grandchildren born, and therefore the chances of passing on the mutated genes from one generation to the next is also limited," Dr da Silva says.

However, the "grandmother effect" does not entirely negate the increased fertility caused by breast cancer genes, he says.

"Our change to today's industrial and technological age has been relatively rapid in human history. For most of our existence, we have been hunter-gatherers. During this time, female fertility was limited, and this may have reduced the increase in fertility caused by mutations of these genes."

Dr da Silva says further studies examining modern-day hunter-gatherer societies might shed more light on how and why the spread of these genetic mutations occurs across generations.

Dr Jack da Silva
Senior Lecturer
School of Molecular & Biomedical Science
The University of Adelaide
Phone: +61 8 8313 8083
jack.dasilva@adelaide.edu.au

Dr Jack da Silva | Newswise Science News
Further information:
http://www.adelaide.edu.au

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>