Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mutant Gene Link to West Nile Virus in Horses

04.06.2010
The same mutated gene that makes humans more susceptible to the potentially fatal West Nile virus is also responsible for the virus affecting horses, according to scientists at the University of Adelaide, Australia.

A naturally occurring mutation of the OAS1 gene has now been confirmed as increasing the vulnerability of horses to the West Nile virus, thanks to a study led by Professor David Adelson (University of Adelaide) and conducted by PhD student Jonathan Rios (Texas A&M University).

The results of the study were published last month in the online peer-reviewed science journal PLoS One.

West Nile virus causes inflammation of the brain and spinal cord, resulting in paralysis and death in humans, horses, birds and other species.

"Horses have been seriously affected by the West Nile virus, especially in North America where vaccinations, treatments and the loss of horses have cost countless millions of dollars to horse owners, industry and the community," says Professor Adelson, who is Professor of Bioinformatics and Computational Genetics at the University of Adelaide's School of Molecular & Biomedical Science.

"The OAS gene cluster in horses most closely resembles that of humans. Because previous research had already identified mutations of OAS1 as playing a key role in the vulnerability of mice and humans to the West Nile virus, we felt it was worth investigating this potential link in horses.

"These genetic mechanisms seem to be playing a similar role in humans and horses in terms of allowing the West Nile virus to take its hold on the body.

"We believe this discovery will be of great interest to horse owners and those involved in controlling the spread of the virus. Knowing that a mutated OAS1 gene is playing a key role in this problem, valuable horses could be screened to check for the presence of the mutation and therefore susceptibility to the virus," Professor Adelson says.

According to the Centers for Disease Control and Infection, in 2009 there were 720 reported human cases of West Nile virus across the United States, including more than 30 deaths.

The virus has been found in Africa, Europe, the Middle East, Asia and Oceania as well in North America. Australia remains free of the virus at this stage.

Prof David Adelson | Newswise Science News
Further information:
http://www.adelaide.edu.au

Further reports about: Mutant Nile Delta OAS1 PLoS One Virus West Nile virus genetic mechanism horses

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>