This is what regularly happens in the targeted immunological attack on the myelin sheaths of the nerve cells, as shown experimentally for the first time by researchers from Würzburg and Zürich.
Living tissue from the cerebral cortex of mice: Nerve cells are shown in green, their nuclei in blue. If you add T cells specialized in destroying myelin-generating cells, significant amounts of nerve cells also die off within six hours. They are displayed in red or yellow in the picture. The arrows point to the dead nerve cells. Picture: Heinz Wiendl
Inflammations in the central nervous system can be triggered by viruses or by the immune system. The latter is the case in multiple sclerosis. With drastic consequences: The cells responsible for building and maintaining an insulating sheath around the nerve fibers die off. The sheaths degenerate as well and often even the nerve cells are destroyed eventually.
"In the example of multiple sclerosis, not only the loss of the myelin sheaths but particularly the death of the nerve cells is thought to be decisive for the permanent disabilities that many patients have to deal with," says Professor Heinz Wiendl at the Department of Neurology of the University of Würzburg. Such disabilities include paralysis or impaired vision.
Now, for the first time, two study groups have simultaneously shown that certain T cells of the immune system not only directly affect the myelin-generating cells but also cause "collateral damage" to the nerve cells or their extensions. The research has been published in the journals Glia and American Journal of Pathology.
T cells: Indirect effect causes nerve cells to die
Wiendl's team at the Department of Neurology of the University of Würzburg was able to demonstrate this with brain tissue cultures: T cells exclusively targeting a specific structure on the surface of the myelin-generating cells also caused a significant loss of nerve cells within just a few hours. How this indirect effect might be accounted for is explained by Würzburg researcher Sven Meuth: "Possibly, the T cells release some soluble factors, such as perforin or granzyme B, which in turn migrate to and damage the nerve cells."
Serial murder: Each T cell strikes many times
The aggressive T cells act just like serial killers: "Every single one of them can kill off up to 30 myelin-generating cells and - at the same time - destroy up to ten nerve cells," says Heinz Wiendl.
These T cells virtually cut through the extensions of the nerve cells. This has been established by the team headed by Professor Norbert Goebels of the University of Zürich (now Düsseldorf) in a similar experimental approach by means of video analysis.
Possible target for new therapies
"These results help us to better understand the development of acute and chronic damage in inflammations of the central nervous system," explains Professor Wiendl. In future, the patients might also benefit from the findings - after all, the aggressive T cells are an attractive target for new therapies. Therefore, the Würzburg scientists are eager to find out as much as possible about these serial killers.
Multiple sclerosis: about the disease
Globally, approximately 2.5 million people are affected by multiple sclerosis; in Germany, there are about 122,000 patients according to current estimates. Here, approximately 2,500 new cases of the disease are diagnosed per year. Women aquire the disease almost twice as often as men.
In MS patients, the immune system mistakenly attacks the components of the nervous system, most prominently the nerve sheaths eventually destructing neural cells. Most often, the onset of the disease starts in early adulthood with relapsing remitting neurological symptoms. Initially people affected perceive tingling sensations in arms and legs, have walking disturbances or encounter visual problems. In the course of disease patients often acquire permanent disability. Some of them need a wheel-chair at later stages.
At the moment, there is no cure for multiple sclerosis; however, medical treatment can alleviate the symptoms of the patients and improve their quality of life. The Department of Neurology in Würzburg accommodates more than 2000 MS patients.
Prof. Dr. Heinz Wiendl, Department of Neurology of the University of Würzburg, T ++ 49 (931) 201-23755 or ++ 49 (931)201-23756, firstname.lastname@example.org
Prof. Dr. Norbert Goebels, Department of Neurology of the University of Düsseldorf, email@example.com
"Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack", Göbel K, Melzer N, Herrmann AM, Schuhmann MK, Bittner S, Ip CW, Hünig T, Meuth SG, Wiendl H, Glia 2009, online publiziert am 24. September
"Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss", Sobottka B, Harrer MD, Ziegler U, Fischer K, Wiendl H, Hünig T, Becher B, Goebels N, American Journal of Pathology 2009; 175(3):1160-6, online publiziert am 21. August
"CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability", Melzer N, Meuth SG, Wiendl H, FASEB Journal 2009, online publiziert am 30. Juni
Robert Emmerich | idw
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences