"We want to accelerate the discovery of new compounds that can be turned into effective drugs," said Professor Tony Maxwell from the John Innes Centre, a key player in "More Medicines for Tuberculosis", a new European research project.
Two billion people are currently infected with TB and three million die every year. TB causes more deaths than any other infectious disease. Rates are increasing, especially in sub-Saharan Africa, where people with HIV are particularly vulnerable. It is also associated with intravenous drug use and increased rates may be linked to immigration.
"The bacterium is difficult to get at," said Professor Maxwell. "It is slow growing, spends a lot of time hidden in cells before it makes itself known, and has very tough cell walls of its own."
Treatment is relatively long term, requiring a drug regime over four to six months. Non-compliance is a problem, exacerbating the challenge caused by resistant strains.
"Drug discovery research for tuberculosis is dependent on academic labs and no single lab can do it", said Professor Maxwell.
Scientists from 25 labs across Europe will collaborate on the new project including some groups in the US and India.
The John Innes Centre scientists will focus on compounds that target DNA gyrase, a target that they have already established as effective and safe. They will receive compounds from European collaborators including AstraZeneca. They will screen those that knock out DNA gyrase. Their research will continue on those compounds that are effective both against the target (DNA gyrase) and the bacterium.
Working on new compounds to hit known targets, rather than compounds that may struggle to access bacterial cells or that may have unknown effects in humans, will provide a quicker route to clinical trials.
"Finding new antibiotics that work is only the first step," warns Professor Maxwell.
The next stage will be to determine how exactly the antibiotic compound operates and whether it has a hope of working in a clinical environment.
One group of compounds under study at JIC are naphthoquinones, originally extracted from plants including the toothbrush tree, Euclea natalensis.
The John Innes Centre is an institute of the BBSRC.
Zoe Dunford | EurekAlert!
Atomic-level motion may drive bacteria's ability to evade immune system defenses
24.04.2017 | Indiana University
Two-dimensional melting of hard spheres experimentally unravelled after 60 years
24.04.2017 | University of Oxford
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences