Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Molecule discovered that makes obese people develop diabetes

Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the molecule CXCL5, produced by certain cells in fatty tissue.

The main risk factors for type 2 diabetes are obesity and a sedentary lifestyle. The biomedical community has known for many years that substances produced by fatty tissue are responsible for the link between obesity and diabetes.

"Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes", Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, told SINC.

The results of this new study show that serum levels of a chemokine molecule called CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. This has helped Lluis Fajas's research team to come to a biomedically relevant conclusion: "The CXCL5 molecule helps cause insulin resistance and type 2 diabetes".

The most important part of this study, published in the journal Cell Metabolism, is the discovery that an experimental treatment aimed at inhibiting the action of CXCL5 can help to protect obese mice from develping type 2 diabetes. "If these studies can be confirmed in humans, this treatment would represent a fundamental improvement in the quality of life of obese individuals", the researcher concludes.

Bad habits cause obesity and diabetes

According to the latest data from the Spanish Diabetes Federation (FED), almost 3.5 million people in Spain have diabetes. This illness is most common in Andalusia and Murcia, regions where the highest percentage of people who are obese and sedentary. The specialists agree on the importance of prevention. Avoiding obesity, doing daily physical exercise and giving up smoking are some of the measures that could help to cut the number of diabetes cases by a half.

The International Diabetes Federation (IDF) says that more than 190 million people worldwide currently have diabetes. This figure will rise to 330 million by 2025, due to population growth, the ageing of the population, and increasing urbanisation and sedentary lifestyles. Obesity is the main avoidable risk factor in developing type 2 diabetes. Worldwide, 1.7 billion people are already at high risk of developing a non-contagious, weight-related illness, such as type 2 diabetes.

Obesity can reduce the life expectancy of people with type 2 diabetes by up to eight years, and 80% of people diagnosed with the illness are overweight at the time they are diagnosed.

At least half of all cases of type 2 diabetes among adults could be avoided if they did not put on weight. Taking action on lifestyle, such as changing diet and taking moderate physical exercise, can reduce the risk of developing type 2 diabetes by up to 60%.


Chavey C., Lazennec G., Lagarrigue S., Clapé C., Iankova I., Teyssier J., Annicotte J. S., Schmidt J., Mataki C., Yamamoto H., Sanches R., Guma A., Stich V., Vitkova M., Jardin-Watelet B., Renard E., Strieter R., Tuthill A., Hotamisligil G. S., Vidal-Puig A., Zorzano A., Langin D. y Fajas L. "CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance". Cell Metabolism; 9(4):339-49, abril de 2009.

SINC | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht International team discovers novel Alzheimer's disease risk gene among Icelanders
24.10.2016 | Baylor College of Medicine

nachricht New bacteria groups, and stunning diversity, discovered underground
24.10.2016 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>