Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecular Glue Controls Chromosome Segregation in Oocytes

28.11.2013
The spindle assembly checkpoint (SAC) is a surveillance mechanism that delays cell division until all chromosomes have attached to the spindle poles.

If this mechanism is impaired in oocytes, it can result in chromosome missegregation and production of aneuploid fetuses, leading to abnormalities like Down’s syndrome (trisomy 21), Edward’s syndrome (trisomy 18) or Klinefelter’s syndrome (XXY).


Aneuploid Mouse Egg Cell

The IMBA researcher Kikue Tachibana-Konwalski and her team together with collaborators from the University of Oxford have now discovered that the proper functioning of the SAC in mammalian oocytes depends on the “molecular glue” called cohesin.

Cohesin is essential to hold replicated chromosomes together. Using molecular “scissors” in the form of TEV protease, the researchers inactivated cohesin to generate chromosomes that cannot bi-orient on the spindle and therefore would be expected to activate a checkpoint response and trigger a cell cycle arrest.

Instead, they found that oocytes in which cohesin has been destroyed still divide and produce highly aneuploid eggs. Therefore, cohesin is required for a robust SAC in oocytes. This has important implications for ageing oocytes, where cohesin deterioration will compromise the SAC, leading to chromosome segregation errors.

Original publication in “Current Biology”: “Spindle Assembly Checkpoint of Oocytes Depends on a Kinetochore Structure Determined by Cohesin in Meiosis I”

Kikue Tachibana-Konwalski
Kikue Tachibana-Konwalski was educated in Austria, Japan and the UK. She obtained a BA Hons in Natural Sciences with specialization in Genetics and a PhD in cell cycle and cancer research from Cambridge University. For her postdoctoral research in Kim Nasmyth’s lab in Oxford, she pioneered the use of TEV protease technology in the mouse to study cohesin in female germ cells. Kikue is a group leader at IMBA since November 2011. Her research focuses on the molecular control of the oocyte-to-zygote transition with the goal of understanding female age-related aneuploidy and infertility.
IMBA:
The Institute of Molecular Biotechnology (IMBA) combines fundamental and applied research in the field of biomedicine. Interdisciplinary research groups address functional genetic questions, particularly those related to the origin of disease. IMBA is a subsidiary of the Austrian Academy of Sciences, the leading organization promoting non-university academic basic research in Austria. IMBA was voted as second to top international workplace for postdoctoral researchers, by readers of the US based and online life sciences magazine, The Scientist. imba.oeaw.ac.at
Austrian Academy of Sciences (ÖAW):
Within the Austrian Academy of Sciences, renowned researchers from 28 research institutions have formed a comprehensive knowledge pool covering a wide array of disciplines for the sake of progress in science as a whole. All of the Academy's activities are closely networked at national, EU, and international level with university and non-university partners.

www.oeaw.ac.at

Elena Bertolini | Newswise
Further information:
http://de.imba.oeaw.ac.at/Presse-Foto
http://www.oeaw.ac.at

More articles from Life Sciences:

nachricht Bare bones: Making bones transparent
27.04.2017 | California Institute of Technology

nachricht Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>