If this mechanism is impaired in oocytes, it can result in chromosome missegregation and production of aneuploid fetuses, leading to abnormalities like Down’s syndrome (trisomy 21), Edward’s syndrome (trisomy 18) or Klinefelter’s syndrome (XXY).
Aneuploid Mouse Egg Cell
The IMBA researcher Kikue Tachibana-Konwalski and her team together with collaborators from the University of Oxford have now discovered that the proper functioning of the SAC in mammalian oocytes depends on the “molecular glue” called cohesin.
Cohesin is essential to hold replicated chromosomes together. Using molecular “scissors” in the form of TEV protease, the researchers inactivated cohesin to generate chromosomes that cannot bi-orient on the spindle and therefore would be expected to activate a checkpoint response and trigger a cell cycle arrest.
Instead, they found that oocytes in which cohesin has been destroyed still divide and produce highly aneuploid eggs. Therefore, cohesin is required for a robust SAC in oocytes. This has important implications for ageing oocytes, where cohesin deterioration will compromise the SAC, leading to chromosome segregation errors.
Original publication in “Current Biology”: “Spindle Assembly Checkpoint of Oocytes Depends on a Kinetochore Structure Determined by Cohesin in Meiosis I”Kikue Tachibana-Konwalski
Bare bones: Making bones transparent
27.04.2017 | California Institute of Technology
Link Discovered between Immune System, Brain Structure and Memory
26.04.2017 | Universität Basel
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Life Sciences
27.04.2017 | Physics and Astronomy
27.04.2017 | Earth Sciences