Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecular aberration signals cancer

20.02.2014
Several scientists, including one at Simon Fraser University, have made a discovery that strongly links a little understood molecule, which is similar to DNA, to cancer and cancer survival.

EMBO reports, a life sciences journal published by the European Molecular Biology Organization, has just published online the scientists’ findings about small non-coding RNAs.

While RNA is known to be key to our cells’ successful creation of proteins, the role of small non-coding RNAs, a newly discovered cousin of the former, has eluded scientific understanding for the most part. Until now, it was only surmised that most of these molecules had nothing to do with protein production.

However, scientists at SFU, the University of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous human cells, including breast and lung, in a specific way. The disturbance, which manifests itself as shorter than normal molecular messaging, also occurs at a specific spot on genes.

“These two identifiable characteristics give cancer-causing non-coding RNAs a chemical signature that makes it easy for scientists to identify them in the early stages of many different types of cancer,” says Steven Jones.

The SFU molecular biology and biochemistry professor is this study’s senior author, and the associate director and head of bioinformatics at the B.C. Cancer Agency’s Genome Sciences Centre.

“These molecules’ existence can also be used to classify cancer patients into subgroups of individuals with different survival outcomes,” adds Jones. “While the precise reason why a tumour would change the behaviour of genes in this way is not known, it is likely that it represents a mechanism by which the cancer can subvert and takeover the normally well controlled activity of our genes.”

This study uncovered non-coding RNAs’ cancerous role by using high-throughput sequencing techniques to analyse reams of genetic information on normal and diseased tissue as part of the Cancer Genome Atlas project.

The Cancer Genome Atlas is an ambitious project to characterize the genetic material of more than 500 tumours from more than 20 different cancers. The project provides a goldmine of data for bioinformaticians such as Jones.

Simon Fraser University is consistently ranked among Canada's top comprehensive universities and is one of the top 50 universities in the world under 50 years old. With campuses in Vancouver, Burnaby and Surrey, B.C., SFU engages actively with the community in its research and teaching, delivers almost 150 programs to more than 30,000 students, and has more than 125,000 alumni in 130 countries.

Simon Fraser University: Engaging Students. Engaging Research. Engaging Communities.

Contact:
Steven Jones (Vancouver resident), 604.877.6083, sjones@bcgsc.ca
Carol Thorbes, PAMR, 778.782.3035, cthorbes@sfu.ca
Jenn Currie, B.C. Cancer Agency, communications, 604.675.8106, jenn.currie@bccancer.bc.ca

Photos: http://i.sfu.ca/KMnjeF

Carol Thorbes | EurekAlert!
Further information:
http://www.sfu.ca

Further reports about: Cancer Genom Molecular Target RNA SFU Vancouver Island early stage human cell non-coding RNAs

More articles from Life Sciences:

nachricht Genetic Regulation of the Thymus Function Identified
23.08.2016 | Universität Basel

nachricht Sun protection for plants - Plant substances can protect plants against harmful UV radiation
22.08.2016 | Max-Planck-Institut für Molekulare Pflanzenphysiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: X-ray optics on a chip

Waveguides are widely used for filtering, confining, guiding, coupling or splitting beams of visible light. However, creating waveguides that could do the same for X-rays has posed tremendous challenges in fabrication, so they are still only in an early stage of development.

In the latest issue of Acta Crystallographica Section A: Foundations and Advances , Sarah Hoffmann-Urlaub and Tim Salditt report the fabrication and testing of...

Im Focus: Piggyback battery for microchips: TU Graz researchers develop new battery concept

Electrochemists at TU Graz have managed to use monocrystalline semiconductor silicon as an active storage electrode in lithium batteries. This enables an integrated power supply to be made for microchips with a rechargeable battery.

Small electrical gadgets, such as mobile phones, tablets or notebooks, are indispensable accompaniments of everyday life. Integrated circuits in the interiors...

Im Focus: UCI physicists confirm possible discovery of fifth force of nature

Light particle could be key to understanding dark matter in universe

Recent findings indicating the possible discovery of a previously unknown subatomic particle may be evidence of a fifth fundamental force of nature, according...

Im Focus: Wi-fi from lasers

White light from lasers demonstrates data speeds of up to 2 GB/s

A nanocrystalline material that rapidly makes white light out of blue light has been developed by KAUST researchers.

Im Focus: Every atom counts

Malignant cancer cells not only proliferate faster than most body cells. They are also more dependent on the most important cellular garbage disposal unit, the proteasome, which degrades defective proteins. Therapies for some types of cancer exploit this dependence: Patients are treated with inhibitors, which block the proteasome. The ensuing pile-up of junk overwhelms the cancer cell, ultimately killing it. Scientists have now succeeded in determining the human proteasome’s 3D structure in unprecedented detail and have deciphered the mechanism by which inhibitors block the proteasome. Their results will pave the way to develop more effective proteasome inhibitors for cancer therapy.

In order to understand how cellular machines such as the proteasome work, it is essential to determine their three-dimensional structure in detail. With its...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

A week of excellence: 22 of the world’s best computer scientists and mathematicians in Heidelberg

12.08.2016 | Event News

Towards the connected, automated and electrified automobiles: AMAA conference in Brussels

02.08.2016 | Event News

Clash of Realities 2016: 7th Conference on the Art, Technology and Theory of Digital Games

29.07.2016 | Event News

 
Latest News

New microchip demonstrates efficiency and scalable design

23.08.2016 | Information Technology

Genetic Regulation of the Thymus Function Identified

23.08.2016 | Life Sciences

Biomass turnover time in ecosystems is halved by land use

23.08.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>