This finding may eventually lead to targets for antifungal strategies, the scientists said.
Patricia Carlisle, a Ph.D. student at the Health Science Center, and David Kadosh, Ph.D., assistant professor of microbiology, found that Ume6, a key transcriptional regulator, targets a specific hyphal filament-development mechanism. "No one knew that Ume6 was involved in directing this process," Dr. Kadosh said. "Perhaps we can learn how to mute its signals."
Transcriptional regulators direct the conversion of DNA (deoxyribonucleic acid) into RNA copies. Copies of RNA (ribonucleic acid) are translated into proteins that carry out activity.
Candida albicans preys on hospitalized critical care patients, HIV/AIDS patients, cancer patients and others with weakened immune systems. It is the fourth-leading cause of hospital-acquired infections in the United States.
"The forming of hyphal filaments is very important in tissue invasion and other activities," Dr. Kadosh said.
The findings were featured as a Spotlight article in the September issue of Eukaryotic Cell, a journal of the American Society for Microbiology.Related link: http://ec.asm.org/cgi/reprint/9/9/1320
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