Throughout the lifecycle, injury to the body’s cells occurs naturally, as well as through trauma. Cells have the ability to repair and regenerate themselves, but a defect in the repair process can lead to cardiovascular, neurological, muscular or pulmonary diseases.
Recent discoveries of key genes that control cell repair have advanced the often painstaking search for ways to enhance the repair process. A new study by researchers from the University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School reports that the protein MG53, previously shown to be the key initiator in the cell membrane repair process, has the potential to be used directly as a therapeutic approach to treating traumatic tissue damage. The research, published today, is featured on the cover of Science Translational Medicine.
“We studied the use of MG53 in treating muscular dystrophy by targeting the protein directly to the damaged muscle. The direct application of MG53 slowed the development of the disease by repairing damaged muscle membranes,” said Noah Weisleder, PhD, assistant professor of physiology and biophysics and corresponding author of the study. “Our findings also suggest that MG53 could be used in regenerative medicine to treat other human diseases in which traumatic cell injury occurs.”
The study established methods to produce MG53 protein for use as a drug in different formulations that were effective when applied both inside and outside of damaged cells. Evidence showed that MG53 initiated repair to cell membranes in striated muscles, where it occurs naturally, but also initiated repair mechanisms outside of the muscle cells, providing protection to the tissue and slowing progression of disease. Additional research as part of this study found that the application of the protein as a therapy is safe.
MG53 was discovered in 2008 by Jianjie Ma, PhD, professor and acting chair of physiology and biophysics at UMDNJ-Robert Wood Johnson Medical School, who was the first to specifically pinpoint that the protein was responsible for promoting cell repair.
“We believe this new research could translate into therapeutic treatment for a broad range of diseases, including heart attack, lung injury and kidney disease, as well as muscular dystrophy,” said Dr. Ma, who oversaw this study. “Before clinical trials can begin, we must complete the pre-clinical studies that include additional safety tests and production of MG53 protein that can be used in human patients as a therapeutic drug.”
The study was conducted in conjunction with TRIM-edicine, a privately held biotechnology company spun-off from UMDNJ and created to commercialize the development of novel biopharmaceutical products in which Dr. Ma and Dr. Weisleder hold an interest. The research was funded by grants from the National Institutes of Health (NIH), an NIH Small Business Research Grant, and the Jain Foundation.
About UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL
As one of the nation’s leading comprehensive medical schools, UMDNJ-Robert Wood Johnson Medical School is dedicated to the pursuit of excellence in education, research, health care delivery, and the promotion of community health. In cooperation with Robert Wood Johnson University Hospital, the medical school’s principal affiliate, they comprise one of the nation's premier academic medical centers. In addition, Robert Wood Johnson Medical School has 34 other hospital affiliates and ambulatory care sites throughout the region.
As one of the eight schools of the University of Medicine and Dentistry of New Jersey with 2,800 full-time and volunteer faculty, Robert Wood Johnson Medical School encompasses 22 basic science and clinical departments, hosts centers and institutes including The Cancer Institute of New Jersey, the Child Health Institute of New Jersey, the Center for Advanced Biotechnology and Medicine, the Environmental and Occupational Health Sciences Institute, and the Stem Cell Institute of New Jersey. The medical school maintains educational programs at the undergraduate, graduate and postgraduate levels for more than 1,500 students on its campuses in New Brunswick, Piscataway, and Camden, and provides continuing education courses for health care professionals and community education programs. To learn more about UMDNJ-Robert Wood Johnson Medical School, log on to rwjms.umdnj.edu. Find us online at www.Facebook.com/RWJMS and www.twitter.com/UMDNJ_RWJMS.Research Featured as Cover Story by Science Translational Medicine
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