Since cosmetics and hygiene products generally are exposed to air when used, it is important to use air-exposed fragrance compounds when testing a patient for allergic reactions, and not only the pure fragrance compounds.
‘I have developed methods for chemical analysis that for the first time make it possible to identify fragrance compounds that have been exposed to air and thus become potent allergens in small amounts and that people may come in contact with in consumer products,’ says Johanna Rudbäck at the Department of Chemistry and Molecular Biology, University of Gothenburg.
Fragrance compounds are among the most allergenic substances in our environment and are almost always used in cosmetics and hygiene products.
Rudbäck studied two essential oils containing some of the most common fragrance compounds, sweet orange oil and petitgrain oil. The researchers have previously shown that exposing some common fragrance compounds to air leads to the formation of potent allergens, hydroperoxides in particular.
‘My analyses show that hydroperoxides from the fragrance compounds were present already before the bottles were opened, and the levels increased when the oils were exposed to air. The study shows that the oils didn’t have any natural protection against the formation of allergenic compounds,’ says Rudbäck.
To learn more about what happens when exposing fragrance compounds to air, Rudbäck studied two additional commonly used fragrance compounds, alpha-terpinene and citronellol. Alpha-Terpinene is found in for example tea tree oil and citronellol, from geranium, is one of the six most common fragrance compounds in cosmetics and hygiene products.
The hydroperoxides from the fragrance compounds are generally difficult to identify and quantify. They are unstable and lack UV absorbance, and are very similar and come in several different forms. In addition, they are found in low concentrations in complex mixtures. The new methods involve separation of the hydroperoxides using either liquid or gas chromatography and detection using mass spectrometry.
‘According to EU regulations, cosmetics must be specially labelled when containing fragrance allergens in concentrations exceeding 0.001% in stay-on products such as lotions and 0.01% in rinse-off products such as shampoos,’ says Rudbäck.
Title of the doctoral thesis: Allergenic Oxidation Products from Fragrance Terpenes – Chemical Analysis and Determination of Sensitizing PotencyContact: Johanna Rudbäck, Department of Chemistry and Molecular Biology
Torsten Arpi | idw
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy