Since cosmetics and hygiene products generally are exposed to air when used, it is important to use air-exposed fragrance compounds when testing a patient for allergic reactions, and not only the pure fragrance compounds.
‘I have developed methods for chemical analysis that for the first time make it possible to identify fragrance compounds that have been exposed to air and thus become potent allergens in small amounts and that people may come in contact with in consumer products,’ says Johanna Rudbäck at the Department of Chemistry and Molecular Biology, University of Gothenburg.
Fragrance compounds are among the most allergenic substances in our environment and are almost always used in cosmetics and hygiene products.
Rudbäck studied two essential oils containing some of the most common fragrance compounds, sweet orange oil and petitgrain oil. The researchers have previously shown that exposing some common fragrance compounds to air leads to the formation of potent allergens, hydroperoxides in particular.
‘My analyses show that hydroperoxides from the fragrance compounds were present already before the bottles were opened, and the levels increased when the oils were exposed to air. The study shows that the oils didn’t have any natural protection against the formation of allergenic compounds,’ says Rudbäck.
To learn more about what happens when exposing fragrance compounds to air, Rudbäck studied two additional commonly used fragrance compounds, alpha-terpinene and citronellol. Alpha-Terpinene is found in for example tea tree oil and citronellol, from geranium, is one of the six most common fragrance compounds in cosmetics and hygiene products.
The hydroperoxides from the fragrance compounds are generally difficult to identify and quantify. They are unstable and lack UV absorbance, and are very similar and come in several different forms. In addition, they are found in low concentrations in complex mixtures. The new methods involve separation of the hydroperoxides using either liquid or gas chromatography and detection using mass spectrometry.
‘According to EU regulations, cosmetics must be specially labelled when containing fragrance allergens in concentrations exceeding 0.001% in stay-on products such as lotions and 0.01% in rinse-off products such as shampoos,’ says Rudbäck.
Title of the doctoral thesis: Allergenic Oxidation Products from Fragrance Terpenes – Chemical Analysis and Determination of Sensitizing PotencyContact: Johanna Rudbäck, Department of Chemistry and Molecular Biology
Torsten Arpi | idw
Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
Transport of molecular motors into cilia
28.03.2017 | Aarhus University
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Health and Medicine
30.03.2017 | Health and Medicine
30.03.2017 | Medical Engineering