Close collaboration between four laboratories at the BIMSB led by Stefan Kempa, Christoph Dieterich, Nikolaus Rajewsky and Wei Chen has led to the identification of thousands of gene products, many of which are expressed and are important in stem cell function. This was achieved by precise characterization of all RNA-molecules expressed in the animals’ cells, the so-called transcriptome, without using the genome sequence (Genome Research, July 2011 21: 1193-1200)*.
Planarians are famous for their almost unlimited ability to regenerate any tissue via pluripotent adult stem cells. Their spectacular regenerative capabilities have been studied for more than 100 years. With the development of new molecular and genetics approaches, planarians have recently re-emerged as a model system for the study of regeneration and stem cells.
The scientists at the BIMSB combined two existing and complementary sequencing methods to decipher the transcriptome of the planarian Schmidtea mediterranea without depending on genome sequences. Their approach is of great practical importance since the genomes of many organisms are known to be extremely difficult to assemble, even with the current sequencing technologies.
Furthermore, they also were able to identify several novel gene products (mRNAs) of which they proved that they are specifically expressed in the stem cells. It is the first proteomics study of such scale in this phylum (Platyhelminthes), as Wei Chen pointed out. The catalogue of transcripts assembled in their study, together with the identified peptides, dramatically expands and refines planarian research.
The Berlin Institute for Medical Systems Biology (BIMSB) was launched by the MDC in 2008, supported by start-up funding from the Federal Ministry of Education and Research (BMBF) and the Senate of Berlin. Medical Systems Biology focuses on molecular networks of genes and proteins, their regulation and interaction with each other and their relevance in disease processes. BIMSB works closely with research institutions and networks in Berlin and beyond, in particular with Humboldt University and Charité – Universitätsmedizin Berlin and also with New York University, USA.*De novo assembly and validation of Planaria transcriptome by massive parallel sequencing and shotgun proteomics
Barbara Bachtler | Max-Delbrück-Centrum
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
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