This recognition can be influenced artificially using molecular plastic molding technology. This is done by mixing plastic building blocks with the molecule that is to be bound to. When the plastic has solidified, the molecule is washed away. What is left is an impression that molecules of this sort can then bind to when they encounters the plastic mold.
The problem is that you also get a number of impressions that are not so good and that are not recognized very well by the molecules to be bound to. This can be minimized by trying to understand why impressions are formed and then providing the material with the best possible properties to produce accurate impressions. This can involve using the right solvent or the right temperature, for example.
As one part of his research, Björn C. G. Karlsson at the University of Kalmar in Sweden has studied a plastic system with recognition for the anesthetic bupivacaine. He has run experiments examining the basis for the creation impressions and various ways of minimizing rebinding to the inferior impressions. He has found that the conditions that yield the best recognition for bupivacaine are governed by a balance between water-repellent and hydrophilic interaction. He also found that this balance can be influenced by temperature.
During his doctoral work, Björn C. G. Karlsson developed a method involving computer simulations of plastic binding before they are effectuated and mapping the interplay that takes place between bupivacaine and the plastic building blocks. The results of this mapping revealed why impressions vary in quality, but also what possibilities there are to use the computer as a tool in selecting the right conditions for producing molecular plastic molds.
The second part of his doctoral work involves the production of a plastic that recognizes warfarin, which is the active substance in the blood-thinning drug variously known as Waran, Coumadin, Jantoven, Marevan, or Lawarin. By collocating the results of an study of warfarin's fluorescent properties with its ability to bind to the artificial plastic, Björn Karlsson was able to help develop a new method for measuring the warfarin content of blood plasma.
For this method, Björn C. G. Karlsson, together with his supervisor Professor Ian Nicholls and research engineer Annika Rosengren, received second prize in the Skapa (Create) Foundation's innovation competition.
For more information, please contact Björn C. G. Karlsson, phone: +46 (0)480- 44 62 80; mobile: 046 (0)70-6150444; or at email@example.com.
Pressofficer: Karolina Ekstrand; firstname.lastname@example.org or +46-766 476030
Karolina Ekstrand | idw
Bolstering fat cells offers potential new leukemia treatment
17.10.2017 | McMaster University
Ocean atmosphere rife with microbes
17.10.2017 | King Abdullah University of Science & Technology (KAUST)
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
17.10.2017 | Life Sciences
17.10.2017 | Life Sciences
17.10.2017 | Earth Sciences