Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method yields better dosage of blood-thinning drugs

03.12.2009
Many biological processes are determined by how various molecules in substances recognize and bind to each other. One such example is our immune defense, which is governed by molecules, called antibodies, that recognize and bind to foreign molecules, called antigens. In this way antibodies neutralize the alien molecules. The antibody recognizes the antigen because the antibody has a socket that perfectly matches the structure of the antigen.

This recognition can be influenced artificially using molecular plastic molding technology. This is done by mixing plastic building blocks with the molecule that is to be bound to. When the plastic has solidified, the molecule is washed away. What is left is an impression that molecules of this sort can then bind to when they encounters the plastic mold.

The problem is that you also get a number of impressions that are not so good and that are not recognized very well by the molecules to be bound to. This can be minimized by trying to understand why impressions are formed and then providing the material with the best possible properties to produce accurate impressions. This can involve using the right solvent or the right temperature, for example.

As one part of his research, Björn C. G. Karlsson at the University of Kalmar in Sweden has studied a plastic system with recognition for the anesthetic bupivacaine. He has run experiments examining the basis for the creation impressions and various ways of minimizing rebinding to the inferior impressions. He has found that the conditions that yield the best recognition for bupivacaine are governed by a balance between water-repellent and hydrophilic interaction. He also found that this balance can be influenced by temperature.

During his doctoral work, Björn C. G. Karlsson developed a method involving computer simulations of plastic binding before they are effectuated and mapping the interplay that takes place between bupivacaine and the plastic building blocks. The results of this mapping revealed why impressions vary in quality, but also what possibilities there are to use the computer as a tool in selecting the right conditions for producing molecular plastic molds.

The second part of his doctoral work involves the production of a plastic that recognizes warfarin, which is the active substance in the blood-thinning drug variously known as Waran, Coumadin, Jantoven, Marevan, or Lawarin. By collocating the results of an study of warfarin's fluorescent properties with its ability to bind to the artificial plastic, Björn Karlsson was able to help develop a new method for measuring the warfarin content of blood plasma.

For this method, Björn C. G. Karlsson, together with his supervisor Professor Ian Nicholls and research engineer Annika Rosengren, received second prize in the Skapa (Create) Foundation's innovation competition.

For more information, please contact Björn C. G. Karlsson, phone: +46 (0)480- 44 62 80; mobile: 046 (0)70-6150444; or at bjorn.karlsson@hik.se.

Pressofficer: Karolina Ekstrand; karolina.ekstrand@hik.se or +46-766 476030

Karolina Ekstrand | idw
Further information:
http://www.vr.se

More articles from Life Sciences:

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

nachricht Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Periodic ventilation keeps more pollen out than tilted-open windows

29.03.2017 | Health and Medicine

Researchers discover dust plays prominent role in nutrients of mountain forest ecoystems

29.03.2017 | Earth Sciences

OLED production facility from a single source

29.03.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>