Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method for detecting nitroxyl will boost cardiac drug research

07.07.2009
Wake Forest University scientists have developed a new research tool in the pursuit of heart medications based on the compound nitroxyl by identifying unique chemical markers for its presence in biological systems.

Nitroxyl, a cousin to the blood-vessel relaxing compound nitric oxide, has been shown in studies to strengthen canine heart beats, but research into its potential benefits for humans has been slowed by a lack of specific detection methods.

"I think this is a very powerful tool to help in the development of new drugs for congestive heart failure," said S. Bruce King, a professor of chemistry at Wake Forest who leads the team that conducted the research.

Researchers can generate nitroxyl from precursor chemicals under controlled conditions, but studying the molecule's activity in cells is difficult because its constituent elements—nitrogen, oxygen and hydrogen—react so readily with other molecules. King's research team used compounds that are not present in normal cell biology to produce a reaction that yields the identifying chemical markers.

King has been investigating nitrogen oxide compounds at Wake Forest since 1995. While scientists have established that the human body naturally produces nitric oxide, natural production of nitroxyl is suspected but has not been demonstrated. King said the new chemical markers could help answer that question, as well.

The research is described in an article, "Reductive Phosphine-Mediated Ligation of Nitroxyl (HNO)," published online in the American Chemical Society's journal Organic Letters. King co-authored the paper with Wake Forest graduate chemistry students Julie Reisz and Erika Klorig, and chemistry department staff member Marcus Wright, an instrumentation manager.

King's research team has received support from the National Institutes of Health, the National Science Foundation, the American Heart Association and the North Carolina Biotechnology Center.

Eric Frazier | EurekAlert!
Further information:
http://www.wfu.edu

Further reports about: Nitroxyl cell biology chemical markers heart medications nitric oxide

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>