Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Melanoma uses body's immune system to spread to lungs

08.10.2010
The way melanoma cells use the immune system to spread and develop into lung tumors may lead to a therapy to decrease development of these tumors, according to Penn State researchers.

"Melanoma is the most aggressive and metastatic form of skin cancer," said Gavin Robertson, professor of pharmacology, pathology, dermatology and surgery in the Penn State College of Medicine. "Therefore, identifying proteins and molecular mechanisms that regulate metastasis is important for developing drugs to treat this disease."

Metastasis is a complex process in which cancer cells detach from the primary tumor and migrate to other sites in the body by traveling through the lymphatic or blood circulatory systems. Researchers in the Foreman Foundation Melanoma Research Laboratory at Penn State developed a model to determine why the roughly one million tumor cells shed daily from a 1-gram melanoma tumor do not form more metastases in the lungs.

After intravenously injecting 1 million human melanoma cells in a mouse, Robertson and colleagues observed entrapment of many of these cells in the lung vessels. Within 24 hours, however, few cells were still present in the lungs.

"In this study, we show that entrapped, circulating melanoma cells can use a person's own immune cells -- specifically a type of white blood cell called neutrophils -- to control lung metastasis development," Robertson said. After injecting the mice with neutrophils an hour following the melanoma cell injection, cancer cell retention was increased in the lung by about three times.

Melanoma cells produce and secrete high levels of a protein called IL-8, which is used to attract neutrophils.

"For patients, this is important because a therapy preventing circulating melanoma cells from secreting IL-8 would have the potential to decrease lung metastasis development by about 50 percent by disrupting interaction of the cancer cells with neutrophils," Robertson said. "Metastases form by proteins on the melanoma and neutrophils interacting and forming physical connections. These connections promote anchoring of the melanoma cells to the lung vessel walls, enabling the cancer cells to migrate through the wall to form lung metastases."

Decreasing the secretion of IL-8 limits the interaction of melanoma cells with neutrophils, dropping the number of melanoma cells retained in the lungs by about half.

Findings were published in the journal Cancer Research. Funding for the study was provided by the National Institutes of Health and the Foreman Foundation for Melanoma Research.

Other authors on the report are Penn State graduate students Sung Jin Huh of the Department of Pharmacology and Shile Liang of the Department of Bioengineering, assistant professor Arati Sharma of the Department of Pharmacology, and professor Cheng Dong, who all are members of the Melanoma Therapeutics Program at Penn State.

Matt Solovey | EurekAlert!
Further information:
http://www.psu.edu

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>