Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Medicines from the Sea

24.03.2009
For the first time, Norwegian scientists have managed to produce completely new antibiotics from bacteria found in the sea. The eleven species of bacteria that create substances that kill cancerous cells and three other bacteria that produce new antibiotics were discovered by scientists at Norwegian University of Science and Technology (NTNU) and SINTEF. In collaboration with research groups in Moscow and the University of Bergen, they have made breakthroughs in the field of biotechnology.

Never before have Norwegian scientists carried out the entire process from gathering bacteria from the fjords to presenting completely new interesting substances in bottles. Behind their success lies a long and painstaking process of screening, cultivation, isolation and testing.

However, it will still take some time before they can be sure that the process will continue to the phases of commercialisation and medicine production. The NTNU and SINTEF researchers have been bioprospecting for five or six years, searching for interesting substances that are produced by marine bacteria. The wide range of expertise of this research group makes it unique, as it brings together competence in physiology and genetics, and has access to modern screening and fermentation laboratories.

The pace of the process has risen during the past few months, since the recruitment of Professor Stein Ove Døskeland’s group at the University of Bergen, one of the best groups around in this field. The scientists have also had bacterial fractions tested in Russia.

Many of the bacteria that have been brought up from the Trondheim Fjord have antibiotic functions, but most of these are already known, and are therefore of no interest. New compounds that can be patented are most interesting. “Substances with a new chemical structure and, we hope, with a different mechanism of action than we already know of, could be extremely valuable, for example in fighting cancer. This is why we need more candidate structures. Not all of them can be developed into new medicines, but if we are successful with one or two of them, we will be quite happy,” says NTNU professor Sergey Zotchev.

Recent focus on a few selected bacteria has led to these exciting findings. In Bergen and Moscow, the 11 anti-cancer substances have been tested against leukemias and stomach, colon and prostate cancers. “We have found that cancerous cells have been killed, while normal cells survive, and that individual extracts act on different types of cancer cells,” says senior scientist Håvard Sletta of SINTEF. “However, we still have not identified the active substances in the compounds produced by the bacteria”.

Meticulous laboratory experiments have enable the scientists to identify the chemical structure of one of the three substances that can be used as antibiotics, and which they now know act against multiresistant bacteria. Towards the end of March, this substance is due to be tested on animals in Moscow. If the results turn out to be positive, the way will be clear for a patent application.

| SINTEF News
Further information:
http://www.sintef.no/Home/Press-Room/Research-News/Medicines-from-the-Sea2/
http://www.kooperation-international.de

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>