Now, Dr. Dinis Pedro Calado and Dr. Klaus Rajewsky of the Max Delbrück Center (MDC) have identified subgroups of B cells in germinal centers in which the proto-oncogene Myc, a critical regulator of cellular proliferation, is highly activated.
In germinal centers (here: whithin the spleen of a mouse) immune cells learn to fight pathogens with high specificity. Dr. Dinis Calado and Dr. Klaus Rajewsky now identified subpopulations of B cells at the germinal centers which express the proto-oncogene Myc (red). They showed that Myc is essential for the formation and maintenance of germinal centers. Their findings have implications for the pathogenesis of B-cell lymphomas.
(Photo: Dinis Calado/ Copyright: MDC)
What then is the role of the Myc gene? How can Myc be highly activated through translocations in B-cell lymphomas although it is not active in healthy B cells of the germinal center reaction? Dr. Calado and Dr. Rajewsky have now found an answer to this question. They identified subpopulations of B cells located in the germinal centers in which the Myc gene is activated. They also showed that c-Myc is essential for the formation and maintenance of the germinal centers. When they knocked out the Myc gene in B cells they could show that germinal centers could not be formed or maintained.
“The MYC-positive germinal center B-cell subpopulations are probably at high risk for malignant transformation. Our work has direct implications for the understanding of the pathogenesis of human germinal center-derived B-cell lymphomas carrying MYC chromosomal translocations and therefore can contribute to a better understanding of how these lymphomas occur,” Dr. Calado and Dr. Rajewsky said.*The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
Barbara Bachtler | Max-Delbrück-Centrum
Further reports about: > B cells > B-cell > B-cell lymphoma > Burkitt lymphoma > DNA > DNA modification > Immunology > MDC > Medical Wellness > Molecular Target > Myc expression > Nature Immunology > Oncology > Pathology > cellular proliferation > cellular protein > chromosomal translocation > immunoglobulin loci > juxtapose Myc > lymph node > lymphoma > malignant transformation
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