Touch can be comforting, raise a person’s spirits and even evoke feelings of happiness. The sensation of touch begins in our skin or more specifically, in certain cells whose nerve endings (neurites) are distributed throughout our skin.
Some of these cells are so incredibly sensitive that even Prof. Gary Lewin and Dr. Kate Poole, who have been studying the “mechanoreception” of the touch sensation for years, were surprised by their findings.
The two scientists of the Max Delbrück Center (MDC) Berlin-Buch and their team of researchers have developed a system with which molecular-scale mechanical stimuli can be exerted on a single cell (Nature Communications, doi: 10.1038/ ncomms4520)*.
The most sensitive of these cells “react to mechanical changes on their surface in the order of magnitude of a few millionths of a millimeter,” said Dr. Poole. “For a pain-sensitive cell to respond – it functions like a mechanoreceptive cell – a considerably stronger stimulus is needed,” the biologist said, explaining the latest experiments of the MDC researchers. These findings could be important to develop new therapies for people with neuropathic pain, for example, for shingles. For these patients, the slightest touch is painful.
In their previous work the Berlin researchers showed that the mechanoreceptive cells are crucial for the sensation of touch – but only in the context of their surroundings, the so-called matrix and its constituent molecules. Pressure or movement of the skin acts on both the matrix and the embedded nerve endings simultaneously.
To unlock the secrets of the sense of touch, the scientists created an artificial system that mimics real-world conditions. It looks like a tiny nail cushion just a few thousandths of a millimeter in size. This system allows very fine and defined mechanical stimuli to be exerted on mechanosensitive cells – via their connection with the matrix. Simultaneously with matrix movement the researchers can directly measure the electrical response of the cell.
Dr. Poole and the research team were amazed to find that if one single nail within the special nail cushion is displaced by just a ten millionth of a millimeter, mechanosensitive cells react and transduce the stimulus, in the intact organism to the brain.
Apparently, mammals have groups of touch sensors with different levels of sensitivity. Pain-sensitive cells from the skin of the mouse, however, must be mechanically stimulated 1000 times stronger before they are activated. “That makes sense,” said study leader Professor Lewin, “otherwise we would often feel pain unnecessarily.”
In a second step, the MDC researchers wanted to know what molecules mediate the significantly different sensitivity of touch and pain sensory cells. The result: a protein named Stoml3 substantially controls the variation in the sensitivity to mechanical stimuli. “When the gene for Stoml3 is inactivated,” Dr. Poole said, “the differences in mechanosensitivity sensitivity almost completely disappear.”
According to the findings of the MDC researchers, Stoml3 modulates the activity and sensitivity of two so-called ion channels in the membranes of many different cell types. These ion channels are called Piezo1 and Piezo2. “Our findings strongly indicate that Piezo2 is involved in touch perception and transduces the appropriate signals, under powerful regulatory control by Stoml3,” Professor Lewin added.
Understanding how Stoml3 works exactly could open up new ways to combat neuropathic pain. The researchers are seeking to block the hypersensitive touch sensors in the skin of patients. According to Lewin, Stoml3 provides a very good target for this. A potentially interesting aspect of this study: An anesthetic injection, e.g. by the dentist, numbs all feeling in the tissue. By contrast, this new form of therapy would only inhibit the conversion of mechanical stimuli into electrical signals. “Otherwise you could continue to feel everything,” said Lewin, “heat, cold, and so on.”
*Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
Kate Poole1,*, Regina Herget1, Liudmila Lapatsina1, Ha-Duong Ngo2 and Gary R. Lewin1,*
Affiliations:1 Department of Neuroscience, Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany.
2Microsensor & Actuator Technology, Technische Universität Berlin, D-13355 Berlin, Germany.
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
Barbara Bachtler | Max-Delbrück-Centrum
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy