Malaria parasites alter the chemical odor signal of their hosts to attract mosquitos and better spread their offspring, according to researchers, who believe this scent change could be used as a diagnostic tool.
"Malaria-infected mice are more attractive to mosquitos than uninfected mice," said Mark Mescher, associate professor of entomology, Penn State. "They are the most attractive to these mosquito vectors when the disease is most transmissible."
Malaria in humans and animals is caused by parasites and can be spread only by an insect vector, a mosquito. The mosquito ingests the parasite with a blood meal, and the parasite creates the next generation in the mosquito's gut. These nascent parasites travel to the mosquito's salivary glands and are passed to the host during the next meal.
"We were most interested in individuals that are infected with the malaria parasite but are asymptomatic," said Consuelo De Moraes, professor of entomology, Penn State. "Asymptomatic people can still transmit the disease unless they are treated, so if we can identify them we may be able to better control the disease."
The researchers found that using a mouse malaria model, the mosquitos were more attracted to infected mice, even when the mice were otherwise asymptomatic. They report their findings today (June 30) in the Proceedings of the National Academy of Sciences.
The researchers, who also included Nina M. Stanczyk, former postdoctoral fellow; Heike S. Betz, research technologist, entomology; Hannier Pulido, graduate student in entomology; Derek G. Sim, technician, senior research assistant, biology; and Andrew F. Read, Alumni Professor in the Biological Sciences and Professor of Entomology, all of Penn State, also showed that several individual compounds whose concentrations were altered by malaria infection contributed to the increase in attractiveness to mosquitoes.
To eliminate other factors such as carbon dioxide production and body temperature as an attractant, the researchers extracted the body scent from the mice and showed that the changes in the scent alone altered the attraction of mosquitoes.
"Mosquitos wouldn't opt to carry the malaria parasite because it isn't good for the mosquito," said De Moraes. "Probably the parasite is not only manipulating the mice to alter their scent, but the mosquitos to be more attracted to the infected scent."
While the mosquitos were not attracted to mice that had acute malaria symptoms, they were particularly attracted to mice during a period of recovery when the transmissible stage of the malaria parasite was present at high levels.
In regions where malaria is prevalent, significant numbers of people harbor asymptomatic infections but remain able to transmit the disease to others. The researchers hope this altered scent profile might help to identify those needing treatment.
"If this holds true in humans, we may be able to screen humans for the chemical scent profile using this biomarker to identify carriers," said Mescher.
The Bill and Melinda Gates Foundation Grand Challenges Exploration supported this work.
A'ndrea Elyse Messer | Eurek Alert!
Surprising similarity in fly and mouse motion vision
30.07.2015 | Max Planck Institute of Neurobiology, Martinsried
Intracellular microlasers could allow precise labeling of a trillion individual cells
30.07.2015 | Massachusetts General Hospital
Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.
The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight
A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...
Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.
By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...
Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.
While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...
23.07.2015 | Event News
10.07.2015 | Event News
25.06.2015 | Event News
30.07.2015 | Life Sciences
30.07.2015 | Trade Fair News
30.07.2015 | Awards Funding