New cyclotron produces radioactive isotopes for nuclear chemistry to be applied in basic research and the development of clinical applications
A new particle accelerator will further enhance the research landscape at Johannes Gutenberg University Mainz (JGU). It is to be employed to conduct research into potential applications of medical relevance. The new cyclotron has been installed in a basement structure of the Institute of Nuclear Chemistry on the Gutenberg Campus.
It will be used to generate short half-life isotopes, which will be principally used for fundamental research but are also required for the medical imaging technique known as positron emission tomography (PET). The cost of this large-scale research device amounts to about EUR 1 million provided by the German Research Foundation (DFG) and the Rhineland-Palatinate Research Initiative. Commissioning of the new cyclotron is planned for spring 2016.
The cyclotron is a ring-shaped particle accelerator that occupies a floor space of some 7.5 square meters and has a height of two meters. It weighs about 50 tons and a crane had to be used to lower it through a hole in the ceiling into the designated basement room. In addition to the cyclotron room, the new structure has a technical and control center together with an access lock. The structure is linked directly to the Institute of Nuclear Chemistry extension building and has all safety-relevant features.
As it will be able to accelerate protons to an energy of 9.7 mega-electron volts (MeV), the cyclotron at Mainz University can be used to generate the two radioactive elements fluorine-18 and carbon-11. These will be mainly employed for chemical and pharmaceutical research purposes but are also necessary for the PET medical diagnostic imaging technique.
F-18 and C-11 have short half-lives of just 110 and 20 minutes respectively. It is thus necessary to generate them near the location at which they are to be used to ensure that they are available in sufficient quantities. It has not previously been possible in Mainz to create radiopharmaceuticals labeled with C-11 because of its particularly short half-life. The new accelerator has now made this feasible.
"The cyclotron will enhance our currently existing infrastructure and eliminate a bottleneck in the production of radioactive nuclides," explained Professor Frank Rösch of the JGU Institute of Nuclear Chemistry. "It will significantly facilitate the development of new radiopharmaceuticals and their preclinical evaluation while – working in collaboration with the Department of Nuclear Medicine at the Mainz University Medical Center – we will be able to markedly expedite their future application in patient diagnosis."
There are additional benefits to be expected through interdisciplinary joint projects in which the areas of nuclear chemistry, pharmaceutical sciences, organic chemistry, and nuclear medicine at JGU will collaborate with regard to the development and evaluation of new PET radiopharmaceuticals, in some cases also with external institutions such as the Department of Psychiatry, Psychotherapy, and Psychosomatics at RWTH Aachen and the Mainz-based Max Planck Institute for Polymer Research.
Installation of the cyclotron on the campus of Johannes Gutenberg University Mainz
photo/©: Heinz-Martin Schmidt
Installment of a cyclotron door into the newly constructed cyclotron building
photo/©: Heinz-Martin Schmidt
(fltr) Professor Tobias Reich (Managing Director of the Institute of Nuclear Chemistry), Professor Norbert Trautmann (Institute of Nuclear Chemistry), Dr. Waltraud Kreutz-Gers (Chancellor of Johannes Gutenberg University Mainz), Professor Georg Krausch (President of Johannes Gutenberg University Mainz), and Professor Frank Rösch (Institute of Nuclear Chemistry) observing the installation of the new cyclotron
Professor Dr. Frank Rösch
Institute of Nuclear Chemistry
Johannes Gutenberg University Mainz (JGU)
55099 Mainz, GERMANY
phone +49 6131 39-25302
fax +49 6131 39-24692
http://www.kernchemie.uni-mainz.de – Institute of Nuclear Chemistry
http://www.uni-mainz.de/presse/19663_ENG_HTML.php – press release "German Research Foundation, Rhineland-Palatinate, and Mainz University invest more than
EUR 2 million in a cyclotron and its building complex" (19 October 2015)
http://www.uni-mainz.de/presse/20010_ENG_HTML.php - press release ;
http://www.kernchemie.uni-mainz.de/eng/index.php - Institute of Nuclear Chemistry ;
http://www.uni-mainz.de/presse/19663_ENG_HTML.php - press release "German Research Foundation, Rhineland-Palatinate, and Mainz University invest more than EUR 2 million in a cyclotron and its building complex" (19 Oct. 2015)
Petra Giegerich | idw - Informationsdienst Wissenschaft
Rutgers scientists discover 'Legos of life'
23.01.2018 | Rutgers University
Researchers identify a protein that keeps metastatic breast cancer cells dormant
23.01.2018 | Institute for Research in Biomedicine (IRB Barcelona)
Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.
Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
23.01.2018 | Life Sciences
23.01.2018 | Earth Sciences
23.01.2018 | Physics and Astronomy