Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mainz and Freiburg immunologists discover immune system precursor cells that fight infection

26.05.2014

Evidence presented of the existence of a previously unknown form of lymphocyte that protects against intracellular infection

The innate immune system recognizes infectious agents such as viruses and bacteria. A group of lymphocytes known as "innate lymphoid cells" or ILCs plays a central role in the defense of the human body against infective agents.

Professor Andreas Diefenbach of the Research Center Immunology at the Mainz University Medical Center, working in collaboration with scientists at the University of Freiburg, has discovered previously unidentified ILCs that are able to protect epithelial surfaces, such as those of the intestinal mucosa, against infection.

The results provide important additional insights into how the immune system functions. It is also possible that these findings, recently published in the international journal Cell, could result in the development of new vaccination strategies that would prevent intracellular infections.

... more about:
»Hygiene »ILC »discover »immune »infections »unknown

ILCs are among the most important weapons of the innate immune system and help it to fight infections and prevent the development of cancer. However, ILCs are not only of critical importance when it comes to preventing infections. They also have important functions in non-immunological processes, such as organ homeostasis, i.e., the maintenance of the physiological functional status of vital organs.

Professor Andreas Diefenbach, Director of the Department of Medical Microbiology and Hygiene at the Mainz University Medical Center, has now identified a previously unrecognized ILC population. Specifically, he has been able to identify previously unknown precursor cells from which all types of ILCs may originate and to describe a new ILC subgroup called type 1 ILCs.

"The fact that we have found the potential precursor cell for all ILCs has opened up completely new horizons for research in the field of immunology. We now have a realistic chance of identifying the signals controlling differentiation of such precursor cells into each of the various ILC types," said Diefenbach.

"If we understand how distinct types of ILCs are involved in the development of inflammatory bowel diseases and autoimmune disorders, we may be able to precisely suppress this unwanted programming of ILCs in the future." Diefenbach succeeded in detecting the unknown ILCs and the precursor cell at the molecular genetic level with the aid of fluorescent proteins.

"A healthy immune system is the key to preventing illnesses. So it is all the more important for us to obtain a comprehensive understanding of how the immune system operates. With this discovery, Professor Andreas Diefenbach and his team have made additional important progress in understanding the immune system in all its facets," stated the Chief Scientific Officer of the Mainz University Medical Center, Professor Ulrich Förstermann.

Further information:
Professor Dr. Andreas Diefenbach
Department of Medical Microbiology and Hygiene
Mainz University Medical Center
phone +49 6131 17-9363
fax 06131 17-9021
e-mail: andreas.diefenbach@uni-mainz.de

Press contact:
Oliver Kreft
Press and Public Relations
Mainz University Medical Center
phone +49 6131 17-7424
fax +49 6131 17-3496
e-mail: pr@unimedizin-mainz.de

About the University Medical Center of Johannes Gutenberg University Mainz
The University Medical Center of Johannes Gutenberg University Mainz is the only facility of its kind in Rhineland-Palatinate. It consists of more than 60 clinics, institutes, and departments. Research and teaching are inextricably linked with medical treatment. Approximately 3,500 students of medicine and dentistry are trained in Mainz on a continuous basis. More information can be found at http://www.unimedizin-mainz.de/index.php?L=1

Weitere Informationen:

http://www.uni-mainz.de/presse/17302_ENG_HTML.php - press release ;
http://www.sciencedirect.com/science/article/pii/S009286741400405X - abstract

Petra Giegerich | idw - Informationsdienst Wissenschaft

Further reports about: Hygiene ILC discover immune infections unknown

More articles from Life Sciences:

nachricht A cell senses its own curves: New research from the MBL Whitman Center
29.04.2016 | Marine Biological Laboratory

nachricht A New Discovery in the Fight against Cancer: Tumor Cells Switch to a Different Mode
29.04.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Tiny microbots that can clean up water

Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.

Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...

Im Focus: ORNL researchers discover new state of water molecule

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...

Im Focus: Bionic Lightweight Design researchers of the Alfred Wegener Institute at Hannover Messe 2016

Honeycomb structures as the basic building block for industrial applications presented using holo pyramid

Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...

Im Focus: New world record for fullerene-free polymer solar cells

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...

Im Focus: Ultra-thin glass is up and coming

As one of the leading R&D partners in the development of surface technologies and organic electronics, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP will be exhibiting its recent achievements in vacuum coating of ultra-thin glass at SVC TechCon 2016 (Booth 846), taking place in Indianapolis / USA from May 9 – 13.

Fraunhofer FEP is an experienced partner for technological developments, known for testing the limits of new materials and for optimization of those materials...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The “AC21 International Forum 2016” is About to Begin

27.04.2016 | Event News

Soft switching combines efficiency and improved electro-magnetic compatibility

15.04.2016 | Event News

Grid-Supportive Buildings Give Boost to Renewable Energy Integration

12.04.2016 | Event News

 
Latest News

Winds a quarter the speed of light spotted leaving mysterious binary systems

29.04.2016 | Physics and Astronomy

Fiber optic biosensor-integrated microfluidic chip to detect glucose levels

29.04.2016 | Health and Medicine

A cell senses its own curves: New research from the MBL Whitman Center

29.04.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>