Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mainz and Freiburg immunologists discover immune system precursor cells that fight infection

26.05.2014

Evidence presented of the existence of a previously unknown form of lymphocyte that protects against intracellular infection

The innate immune system recognizes infectious agents such as viruses and bacteria. A group of lymphocytes known as "innate lymphoid cells" or ILCs plays a central role in the defense of the human body against infective agents.

Professor Andreas Diefenbach of the Research Center Immunology at the Mainz University Medical Center, working in collaboration with scientists at the University of Freiburg, has discovered previously unidentified ILCs that are able to protect epithelial surfaces, such as those of the intestinal mucosa, against infection.

The results provide important additional insights into how the immune system functions. It is also possible that these findings, recently published in the international journal Cell, could result in the development of new vaccination strategies that would prevent intracellular infections.

... more about:
»Hygiene »ILC »discover »immune »infections »unknown

ILCs are among the most important weapons of the innate immune system and help it to fight infections and prevent the development of cancer. However, ILCs are not only of critical importance when it comes to preventing infections. They also have important functions in non-immunological processes, such as organ homeostasis, i.e., the maintenance of the physiological functional status of vital organs.

Professor Andreas Diefenbach, Director of the Department of Medical Microbiology and Hygiene at the Mainz University Medical Center, has now identified a previously unrecognized ILC population. Specifically, he has been able to identify previously unknown precursor cells from which all types of ILCs may originate and to describe a new ILC subgroup called type 1 ILCs.

"The fact that we have found the potential precursor cell for all ILCs has opened up completely new horizons for research in the field of immunology. We now have a realistic chance of identifying the signals controlling differentiation of such precursor cells into each of the various ILC types," said Diefenbach.

"If we understand how distinct types of ILCs are involved in the development of inflammatory bowel diseases and autoimmune disorders, we may be able to precisely suppress this unwanted programming of ILCs in the future." Diefenbach succeeded in detecting the unknown ILCs and the precursor cell at the molecular genetic level with the aid of fluorescent proteins.

"A healthy immune system is the key to preventing illnesses. So it is all the more important for us to obtain a comprehensive understanding of how the immune system operates. With this discovery, Professor Andreas Diefenbach and his team have made additional important progress in understanding the immune system in all its facets," stated the Chief Scientific Officer of the Mainz University Medical Center, Professor Ulrich Förstermann.

Further information:
Professor Dr. Andreas Diefenbach
Department of Medical Microbiology and Hygiene
Mainz University Medical Center
phone +49 6131 17-9363
fax 06131 17-9021
e-mail: andreas.diefenbach@uni-mainz.de

Press contact:
Oliver Kreft
Press and Public Relations
Mainz University Medical Center
phone +49 6131 17-7424
fax +49 6131 17-3496
e-mail: pr@unimedizin-mainz.de

About the University Medical Center of Johannes Gutenberg University Mainz
The University Medical Center of Johannes Gutenberg University Mainz is the only facility of its kind in Rhineland-Palatinate. It consists of more than 60 clinics, institutes, and departments. Research and teaching are inextricably linked with medical treatment. Approximately 3,500 students of medicine and dentistry are trained in Mainz on a continuous basis. More information can be found at http://www.unimedizin-mainz.de/index.php?L=1

Weitere Informationen:

http://www.uni-mainz.de/presse/17302_ENG_HTML.php - press release ;
http://www.sciencedirect.com/science/article/pii/S009286741400405X - abstract

Petra Giegerich | idw - Informationsdienst Wissenschaft

Further reports about: Hygiene ILC discover immune infections unknown

More articles from Life Sciences:

nachricht Molecular evolution: How the building blocks of life may form in space
26.04.2018 | American Institute of Physics

nachricht Multifunctional bacterial microswimmer able to deliver cargo and destroy itself
26.04.2018 | Max-Planck-Institut für Intelligente Systeme

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>