Evidence presented of the existence of a previously unknown form of lymphocyte that protects against intracellular infection
The innate immune system recognizes infectious agents such as viruses and bacteria. A group of lymphocytes known as "innate lymphoid cells" or ILCs plays a central role in the defense of the human body against infective agents.
Professor Andreas Diefenbach of the Research Center Immunology at the Mainz University Medical Center, working in collaboration with scientists at the University of Freiburg, has discovered previously unidentified ILCs that are able to protect epithelial surfaces, such as those of the intestinal mucosa, against infection.
The results provide important additional insights into how the immune system functions. It is also possible that these findings, recently published in the international journal Cell, could result in the development of new vaccination strategies that would prevent intracellular infections.
ILCs are among the most important weapons of the innate immune system and help it to fight infections and prevent the development of cancer. However, ILCs are not only of critical importance when it comes to preventing infections. They also have important functions in non-immunological processes, such as organ homeostasis, i.e., the maintenance of the physiological functional status of vital organs.
Professor Andreas Diefenbach, Director of the Department of Medical Microbiology and Hygiene at the Mainz University Medical Center, has now identified a previously unrecognized ILC population. Specifically, he has been able to identify previously unknown precursor cells from which all types of ILCs may originate and to describe a new ILC subgroup called type 1 ILCs.
"The fact that we have found the potential precursor cell for all ILCs has opened up completely new horizons for research in the field of immunology. We now have a realistic chance of identifying the signals controlling differentiation of such precursor cells into each of the various ILC types," said Diefenbach.
"If we understand how distinct types of ILCs are involved in the development of inflammatory bowel diseases and autoimmune disorders, we may be able to precisely suppress this unwanted programming of ILCs in the future." Diefenbach succeeded in detecting the unknown ILCs and the precursor cell at the molecular genetic level with the aid of fluorescent proteins.
"A healthy immune system is the key to preventing illnesses. So it is all the more important for us to obtain a comprehensive understanding of how the immune system operates. With this discovery, Professor Andreas Diefenbach and his team have made additional important progress in understanding the immune system in all its facets," stated the Chief Scientific Officer of the Mainz University Medical Center, Professor Ulrich Förstermann.
Professor Dr. Andreas Diefenbach
Department of Medical Microbiology and Hygiene
Mainz University Medical Center
phone +49 6131 17-9363
fax 06131 17-9021
Press and Public Relations
Mainz University Medical Center
phone +49 6131 17-7424
fax +49 6131 17-3496
About the University Medical Center of Johannes Gutenberg University Mainz
The University Medical Center of Johannes Gutenberg University Mainz is the only facility of its kind in Rhineland-Palatinate. It consists of more than 60 clinics, institutes, and departments. Research and teaching are inextricably linked with medical treatment. Approximately 3,500 students of medicine and dentistry are trained in Mainz on a continuous basis. More information can be found at http://www.unimedizin-mainz.de/index.php?L=1
http://www.uni-mainz.de/presse/17302_ENG_HTML.php - press release ;
http://www.sciencedirect.com/science/article/pii/S009286741400405X - abstract
Petra Giegerich | idw - Informationsdienst Wissenschaft
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy