Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Lymphoma Treatment Shows Promise in Dogs

09.09.2010
Researchers have identified a new target for the treatment of lymphoma and are testing a potential new drug in pet dogs afflicted with the disease. At low doses, the compound, called S-PAC-1, arrested the growth of tumors in three of six dogs tested and induced partial remission in a fourth.

The results of the study, conducted by researchers at the University of Illinois, appear this month in the journal Cancer Research.

The new compound targets a cellular enzyme, procaspase-3, that when activated spurs a cascade of reactions that kill the cell, said chemistry professor Paul Hergenrother, who co-led the study with Tim Fan, a professor of veterinary clinical medicine.

Procaspase-3 offers an attractive target for cancer therapy, in part because cancers often interfere with normal cell death, and in part because many tumors – including those found in breast cancer, colon cancer, lung cancer, lymphoma, melanoma and liver cancer – contain high levels of procaspase-3.

“In my lab, we try to think of novel targets and novel approaches to cancer and other diseases,” Hergenrother said. “We think about the pathways that lead to those diseases, and we try to intervene at spots where others have not.”

The new compound is a modified version of a drug the researchers previously tested in mice and one dog.

The original compound, called PAC-1, was found to cause neurological excitation (neurotoxicity) even at low doses, the researchers said. Fan and his colleagues hypothesized that PAC-1, which works in part by grabbing zinc away from other molecules, was crossing the blood/brain barrier and latching onto zinc in the brain.

To prevent the compound from passing into the brain, Hergenrother’s laboratory made a derivative of PAC-1 with an added chemical group, called a sulfonamide. Tests in pet dogs with spontaneously occurring lymphoma showed that the new compound, S-PAC-1, stabilized or reduced the size of tumors in a majority of the animals, without neurotoxicity. Other side effects were mild, and recent adjustments to the treatment protocol have minimized or eliminated them, the researchers report.

If S-PAC-1 proves to be effective and safe as a lymphoma treatment and is approved by the FDA for use in dogs and/or humans (a process that could take years, the researchers emphasized), it will likely be added to the arsenal of drugs already used to combat lymphoma in both dogs and humans. It could be used in combination with other drugs as a first treatment option or serve as a second line of defense if the cancer returns.

Cancer drug combinations must be carefully tailored to avoid “overlapping toxicities,” Fan said, so a drug that effectively treats lymphoma with minimal side effects is very desirable.

The study in pet dogs is also unusual, Fan said, as most studies look at effects in mice and then, if a compound is promising and appears safe, it is tested in clinical trials in humans. The six dogs used in this study were veterinary patients that had spontaneously developed lymphoma, he said.

The similarities between human and canine lymphoma also add to the desirability of this approach, Hergenrother said.

“If you look at the genetic signatures of canine lymphoma and human lymphoma, they’re very, very similar and their response to therapy is very, very similar,” he said. “So there’s lots of reasons to be optimistic about a compound that has some effect in the canines, that it could have a similar effect in humans.”

This study was supported by funding from the National Cancer Institute at the National Institutes of Health. A new $525,000 grant from the NCI will support a clinical trial of S-PAC-1 in companion animal dogs. More information about the upcoming trial is available online: http://vetmed.illinois.edu/vth/MedServices/SmallAnimal/CancerCareClinic/CancerCareClinic.html

Diana Yates | University of Illinois
Further information:
http://www.illinois.edu

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>