This protein, called c-MYC oncoprotein, can initiate and promote almost all human cancers and discovering the role it plays in cancer treatment resistance may lead to advances that save lives.
The work is published in the March 29, 2011 issue of Science Signaling, a publication of the American Association for the Advancement of Science. Although scientists have known that cancer cells can acquire resistance to DNA-damaging therapeutic agents, the genetic mechanisms through which this occurs have remained unclear until now.
Using the chemotherapy drug, cisplatin (which is commonly used as a first-line therapy for various cancers) to design a set of experiments, the research team found that the c-MYC oncoprotein increases cisplatin resistance by decreasing production of a c-MYC inhibitor called BIN1. BIN1 suppressed an enzyme essential for DNA repair, and the sensitivity of cancer cells to cisplatin depended upon BIN1 abundance. Overproducing the c-MYC oncoprotein repressed BIN1, blocking its life-saving action.
"Our study provides a potent and novel mechanism through which cancer acquires resistance to DNA damage," notes Dr. Sakamuro. "Inhibition of oncogenic c-MYC may provide an attractive strategy for cancer therapy in combination with DNA-damaging agents."
The researchers also propose that analyzing the levels of the c-MYC and BIN1 proteins or their mutational status may also serve as a valuable prognostic marker to determine whether a cancer will respond to an aggressive dose of therapeutic agents.
According to the American Cancer Society, about 1,529,560 new cancer cases were expected to be diagnosed in the United States in 2010, excluding noninvasive cancers as well as basal and squamous cell skin cancers. Cancer accounts for nearly one quarter of the deaths in the US with an estimated 569,490 cancer deaths expected last year.
"Our study will determine how we can re-sensitize malignant cancer cells to conventional DNA-damaging therapeutic agents and how we can minimize unnecessary side effects associated with cytotoxic chemo and radiation therapy," adds Dr. Sakamuro.
In addition to LSU Health Sciences Center New Orleans, the research team included scientists from Purdue University, West Lafayette, Indiana.
The research was supported by grants from the US Army Department of Defense, National Institutes of Health, Louisiana Cancer Research Consortium, Susan G. Komen Foundation, Walther Cancer Foundation, and Wendy Will Case Cancer Fund.
Dr. Sakamuro notes that 90% of this research was done at LSU Health Sciences Center New Orleans after Katrina. "When I attend conferences out of town, some people think New Orleans is still under water or struggling to recover. But the fact is the LSUHSC biomedical research facilities are fully recovered and a top notch environment for scientific discovery and success."
LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC New Orleans consists of a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, Schools of Allied Health Professions and Graduate Studies, and the only School of Nursing within an academic health center in the State of Louisiana. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth.
Leslie Capo | EurekAlert!
Gene therapy shows promise for treating Niemann-Pick disease type C1
27.10.2016 | NIH/National Human Genome Research Institute
'Neighbor maps' reveal the genome's 3-D shape
27.10.2016 | International School of Advanced Studies (SISSA)
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences