The LSUHSC researchers are the first to demonstrate that miR-27b, a novel microRNA, not only inactivates the ST14 gene which they found suppresses the growth of breast tumor cells, but also that miR-27b stimulates the breast cancer to invade other cells.
MicroRNAs are a new class of small, single-stranded RNA molecules which play an important regulatory role in cell biology. They bind to target genes and decrease their function. MicroRNAs may act as oncogenes (a gene that contributes to cancer development) or tumor suppressors.
In this study working with a line of human breast cancer cells, Dr. Alahari's team found that aggressively invasive breast tumor cells contain a large quantity of miR-27b molecules, while normal cells do not. Further analysis revealed that miR-27b increases during cancer progression, in direct proportion to the decrease in function of the ST14 gene. They found that miR-27b promotes cell growth and cell invasion, suggesting that miR-27b acts as a breast cancer oncogene. They also found that ST14 inhibits both cell growth and cell invasion, suggesting that ST14 is a breast cancer tumor suppressor gene and that it may also serve as a marker for the early detection of breast cancer.
According to the American Cancer Society, an estimated 192,370 new cases of invasive breast cancer are expected to occur among women in the US during 2009; about 1,910 new cases are expected in men. Excluding cancers of the skin, breast cancer is the most frequently diagnosed cancer in women. An estimated 40,610 breast cancer deaths (40,170 women, 440 men) are expected in 2009. Breast cancer ranks second as a cause of cancer death in women (after lung cancer).
"We are in the process of confirming these results and these studies will reveal whether ST14 can reduce breast tumor growth in animals," notes Dr. Alahari, who is also a member of the LSUHSC Stanley S. Scott Cancer Center. "Blocking the miR-27b/ST14 interaction or rescuing ST14 function may be an effective therapeutic approach to advance breast cancer treatment."
This study was supported by funding from the National Institutes of Health, the Susan G. Komen Breast Cancer Foundation, the Louisiana Board of Regents, and the Louisiana Cancer Research Consortium.
LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's academic health leader, LSUHSC comprises a School of Medicine, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSUHSC faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSUHSC research enterprise generates jobs and enormous economic impact, LSUHSC faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit http://www.lsuhsc.edu and http://www.twitter.com/LSUHSCHealth.
Leslie Capo | EurekAlert!
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology