Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

LSTM Researchers identify the complex mechanisms controlling changes in snake venom

10.06.2014

Study looks at venom variation in closely related snake species

Specialist researchers from LSTM have identified the diverse mechanisms by which variations in venom occur in related snake species and the significant differences in venom pathology that occur as a consequence.

Working with colleagues from Bangor University and Instituto de Biomedicina de Valencia in Spain, the team assessed the venom composition of six related viperid snakes, examining the differences in gene and protein expression that influence venom content. The research, published in PNAS, also assessed how these changes in venom composition impacted upon venom-induced haemorrhage and coagulation pathologies, and how these changes can adversely affect antivenoms used to treat snakebite.

LSTM's Dr Nicholas Casewell, first author and NERC Research Fellow, said: "Our work shows that venom variation observed between related snake species is the result of a complex interaction between a variety of genetic and postgenomic factors acting on toxin genes. This can involve different genes housed in the genome being turned on or off in different snakes at different stages of venom toxin production. Ultimately, the resulting venom variation results in significant differences in venom-induced pathology and lethality and can undermine the efficacy of antivenom therapies used to treat human snakebite victims."

... more about:
»LSTM »Medicine »composition »genes »species »tropical »venom

Every year, snakebites kill up to 90,000 people, mostly in impoverished, rural tropical areas, as well as causing thousands of debilitating injuries to survivors, in part the reason that snakebite has the status of a neglected tropical disease. Antivenom can work but its efficacy is largely restricted to the snake species used in its manufactures and is often ineffective in treating snakebite by different, even closely related species.

LSTM's Dr Robert Harrison, senior author of the study and Head of the Alistair Reid Venom Unit, said: "The findings underscore challenges to developing broad-spectrum snakebite treatments, because conventional antivenom is produced by immunising horses or sheep with the venom from a specific species of snake. Consequently, antivenin produced for one species of saw-scaled viper will not necessarily neutralise the venom of another species of saw-scaled viper, highlighting how changes in venom composition can adversely affect snakebite therapy." 

For further information, please contact:

Mrs Clare Bebb
Senior Media Officer
Liverpool School of Tropical Medicine
Office: +44 (0)151 705 3135
Mobile: +44 (0)7889535222
Email: c.bebb@liv.ac.uk

Liverpool School of Tropical Medicine (LSTM) has been engaged in the fight against infectious, debilitating and disabling diseases since 1898 and continues that tradition today with a research portfolio in excess of well over £200 million and a teaching programme attracting students from over 65 countries.

For further information, please visit: www.lstmliverpool.ac.uk

Clare Bebb | AlphaGalileo

Further reports about: LSTM Medicine composition genes species tropical venom

More articles from Life Sciences:

nachricht Rice University lab runs crowd-sourced competition to create 'big data' diagnostic tools
30.06.2016 | Rice University

nachricht A protein coat helps chromosomes keep their distance
30.06.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Thousands on one chip: New Method to study Proteins

Since the completion of the human genome an important goal has been to elucidate the function of the now known proteins: a new molecular method enables the investigation of the function for thousands of proteins in parallel. Applying this new method, an international team of researchers with leading participation of the Technical University of Munich (TUM) was able to identify hundreds of previously unknown interactions among proteins.

The human genome and those of most common crops have been decoded for many years. Soon it will be possible to sequence your personal genome for less than 1000...

Im Focus: Optical lenses, hardly larger than a human hair

3D printing enables the smalles complex micro-objectives

3D printing revolutionized the manufacturing of complex shapes in the last few years. Using additive depositing of materials, where individual dots or lines...

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

Im Focus: 3-D printing produces cartilage from strands of bioink

Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."

Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Quantum technologies to revolutionise 21st century - Nobel Laureates discuss at Lindau

30.06.2016 | Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

 
Latest News

Modeling NAFLD with human pluripotent stem cell derived immature hepatocyte like cells

30.06.2016 | Health and Medicine

Rice University lab runs crowd-sourced competition to create 'big data' diagnostic tools

30.06.2016 | Life Sciences

A drop of water as a model for the interplay of adhesion and stiction

30.06.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>