Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

LSTM Researchers identify the complex mechanisms controlling changes in snake venom

10.06.2014

Study looks at venom variation in closely related snake species

Specialist researchers from LSTM have identified the diverse mechanisms by which variations in venom occur in related snake species and the significant differences in venom pathology that occur as a consequence.

Working with colleagues from Bangor University and Instituto de Biomedicina de Valencia in Spain, the team assessed the venom composition of six related viperid snakes, examining the differences in gene and protein expression that influence venom content. The research, published in PNAS, also assessed how these changes in venom composition impacted upon venom-induced haemorrhage and coagulation pathologies, and how these changes can adversely affect antivenoms used to treat snakebite.

LSTM's Dr Nicholas Casewell, first author and NERC Research Fellow, said: "Our work shows that venom variation observed between related snake species is the result of a complex interaction between a variety of genetic and postgenomic factors acting on toxin genes. This can involve different genes housed in the genome being turned on or off in different snakes at different stages of venom toxin production. Ultimately, the resulting venom variation results in significant differences in venom-induced pathology and lethality and can undermine the efficacy of antivenom therapies used to treat human snakebite victims."

... more about:
»LSTM »Medicine »composition »genes »species »tropical »venom

Every year, snakebites kill up to 90,000 people, mostly in impoverished, rural tropical areas, as well as causing thousands of debilitating injuries to survivors, in part the reason that snakebite has the status of a neglected tropical disease. Antivenom can work but its efficacy is largely restricted to the snake species used in its manufactures and is often ineffective in treating snakebite by different, even closely related species.

LSTM's Dr Robert Harrison, senior author of the study and Head of the Alistair Reid Venom Unit, said: "The findings underscore challenges to developing broad-spectrum snakebite treatments, because conventional antivenom is produced by immunising horses or sheep with the venom from a specific species of snake. Consequently, antivenin produced for one species of saw-scaled viper will not necessarily neutralise the venom of another species of saw-scaled viper, highlighting how changes in venom composition can adversely affect snakebite therapy." 

For further information, please contact:

Mrs Clare Bebb
Senior Media Officer
Liverpool School of Tropical Medicine
Office: +44 (0)151 705 3135
Mobile: +44 (0)7889535222
Email: c.bebb@liv.ac.uk

Liverpool School of Tropical Medicine (LSTM) has been engaged in the fight against infectious, debilitating and disabling diseases since 1898 and continues that tradition today with a research portfolio in excess of well over £200 million and a teaching programme attracting students from over 65 countries.

For further information, please visit: www.lstmliverpool.ac.uk

Clare Bebb | AlphaGalileo

Further reports about: LSTM Medicine composition genes species tropical venom

More articles from Life Sciences:

nachricht Why do animals fight members of other species?
24.04.2015 | University of California - Los Angeles

nachricht Is a small artificially composed virus fragment the key to a Chikungunya vaccine?
24.04.2015 | Paul-Ehrlich-Institut - Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fast and Accurate 3-D Imaging Technique to Track Optically-Trapped Particles

KAIST researchers published an article on the development of a novel technique to precisely track the 3-D positions of optically-trapped particles having complicated geometry in high speed in the April 2015 issue of Optica.

Daejeon, Republic of Korea, April 23, 2015--Optical tweezers have been used as an invaluable tool for exerting micro-scale force on microscopic particles and...

Im Focus: NOAA, Tulane identify second possible specimen of 'pocket shark' ever found

Pocket sharks are among the world's rarest finds

A very small and rare species of shark is swimming its way through scientific literature. But don't worry, the chances of this inches-long vertebrate biting...

Im Focus: Drexel materials scientists putting a new spin on computing memory

Ever since computers have been small enough to be fixtures on desks and laps, their central processing has functioned something like an atomic Etch A Sketch, with electromagnetic fields pushing data bits into place to encode data.

Unfortunately, the same drawbacks and perils of the mechanical sketch board have been just as pervasive in computing: making a change often requires starting...

Im Focus: Exploding stars help to understand thunderclouds on Earth

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was discovered, more or less by coincidence, that cosmic rays provide suitable probes to measure electric fields within thunderclouds. This surprising finding is published in Physical Review Letters on April 24th. The measurements were performed with the LOFAR radio telescope located in the Netherlands.

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was...

Im Focus: On the trail of a trace gas

Max Planck researcher Buhalqem Mamtimin determines how much nitrogen oxide is released into the atmosphere from agriculturally used oases.

In order to make statements about current and future air pollution, scientists use models which simulate the Earth’s atmosphere. A lot of information such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HHL Energy Conference on May 11/12, 2015: Students Discuss about Decentralized Energy

23.04.2015 | Event News

“Developing our cities, preserving our planet”: Nobel Laureates gather for the first time in Asia

23.04.2015 | Event News

HHL's Entrepreneurship Conference on FinTech

13.04.2015 | Event News

 
Latest News

Electrons Move Like Light in Three-Dimensional Solid

24.04.2015 | Materials Sciences

Connecting Three Atomic Layers Puts Semiconducting Science on Its Edge

24.04.2015 | Materials Sciences

Understanding the Body’s Response to Worms and Allergies

24.04.2015 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>