Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Liquid to gel to bone

12.12.2013
Rice U. develops temperature-sensitive gelling scaffolds to regenerate craniofacial bone

Rice University bioengineers have developed a hydrogel scaffold for craniofacial bone tissue regeneration that starts as a liquid, solidifies into a gel in the body and liquefies again for removal.


Injectable hydrogel scaffold undergoes rapid gelation from a soluble liquid at room temperature, left, to form a stable, nonshrinking gel at body temperature, right, after one minute. (Credit: Mikos Laboratory/Rice University)

The material developed in the Rice lab of bioengineer Antonios Mikos is a soluble liquid at room temperature that can be injected to the point of need. At body temperature, the material turns instantly into a gel to help direct the formation of new bone to replace that damaged by injury or disease.

The gel conforms to irregular three-dimensional spaces and provides a platform for functional and aesthetic tissue regeneration. It is intended as an alternative to prefabricated implantable scaffolds.

The invention is the subject of a new paper that appeared online this week in the American Chemical Society journal Biomacromolecules.

Lead author Tiffany Vo, a fourth-year doctoral graduate student in the Mikos lab, earned a Ruth L. Kirschstein National Research Service Award from the National Institute of Dental and Craniofacial Research for her work on the project.

“This new platform technology leverages injectable, thermally responsive, chemically crosslinkable and bioresorbable hydrogels for regenerative medicine applications,” Mikos said. “It enables the formation of scaffolds locally and the delivery of growth factors and stem cells into defects of complex anatomical shapes with minimal surgical intervention.”

Thermosensitive technologies are not new to the field of tissue engineering and regenerative medicine, Mikos said. What makes the poly(N-isopropylacrylamide), or PNiPAAm, scaffold promising is that its chemical cross-linking technology allows the researchers to eliminate gel shrinkage without reducing swelling; this improves its stability so that it serves as an effective delivery vehicle for growth factors and stem cell populations.

Once sufficient quality and quantity of bone tissue have regenerated to fill the defected site, the hydrogel scaffold can be transitioned back into a liquid state and released naturally.

As part of the project, the researchers will test the hydrogel’s enhanced seeding capabilities and ability to promote cellular attachment, crosstalk and proliferation toward greater bone formation. The knowledge will improve the understanding of biomaterial-based therapies for minimally invasive tissue regeneration as viable clinical alternatives.

“The results demonstrate the ability to encapsulate stem cell populations with temperature-sensitive gelling scaffolds for injectable cell delivery with enormous implications for the development of novel therapeutics for craniofacial bone regeneration,” Mikos said.

Co-authors include Adam Ekenseair, a former postdoctoral fellow in the Mikos Lab and currently an assistant professor of chemical engineering at Northeastern University, and Kurt Kasper, a faculty fellow in bioengineering at Rice. Mikos is Rice’s Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering.

The National Institutes of Health, the Baylor College of Medicine Scientific Training Program for Dental Academic Researchers and the Kirschstein fellowship supported the research.

Read the abstract at http://pubs.acs.org/doi/abs/10.1021/bm401413c
Follow Rice News and Media Relations via Twitter @RiceUNews
Related Materials:
The Mikos Research Group: http://www.ruf.rice.edu/~mikosgrp/
Rice’s BioScience Research Collaborative: http://brc.rice.edu/home/
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,708 undergraduates and 2,374 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 2 for “best value” among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/AboutRiceU.

David Ruth | EurekAlert!
Further information:
http://www.rice.edu

More articles from Life Sciences:

nachricht Zap! Graphene is bad news for bacteria
23.05.2017 | Rice University

nachricht Discovery of an alga's 'dictionary of genes' could lead to advances in biofuels, medicine
23.05.2017 | University of California - Los Angeles

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Scientists propose synestia, a new type of planetary object

23.05.2017 | Physics and Astronomy

Zap! Graphene is bad news for bacteria

23.05.2017 | Life Sciences

Medical gamma-ray camera is now palm-sized

23.05.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>