Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Legalizing marijuana and the new science of weed


More than a year into Colorado's experiment legalizing marijuana, labs testing the plants are able for the first time to take stock of the drug's potency and contaminants -- and openly paint a picture of what's in today's weed. At the 249th National Meeting & Exposition of the American Chemical Society (ACS), one such lab will present trends -- and some surprises -- that its preliminary testing has revealed about the marijuana now on the market.

ACS, the world's largest scientific society, is holding the meeting here through Thursday. It features nearly 11,000 presentations on a wide range of science topics. A brand-new video on the research is available at

Marijuana buds are often two to three times as potent as they were 30 years ago. (An ACS video on this topic is available here

Credit: Charas Scientific (for the photo) and American Chemical Society (for the video)

Three major patterns have emerged over the past few months since Andy LaFrate, Ph.D., and his lab began testing marijuana samples. Those patterns concern potency, amounts of a substance called CBD and contaminants in the products.

"As far as potency goes, it's been surprising how strong a lot of the marijuana is," LaFrate says. "We've seen potency values close to 30 percent THC, which is huge." LaFrate is the president and director of research of Charas Scientific, one of eight labs certified by Colorado to do potency testing.

THC is an abbreviation for tetrahydrocannabinol, which is the psychoactive compound in the plant. He explains that three decades ago, THC levels were well below 10 percent. Its content has tripled in some strains because producers have been cross-breeding them over the years to meet user demands for higher potency, he says.

But an unexpected consequence of this breeding has occurred, says LaFrate. Many of the samples his lab has tested have little to no cannabidiol, or CBD. CBD is a lesser known compound in marijuana that is of increasing interest to medical marijuana proponents. Researchers are investigating CBD as a treatment for schizophrenia, Huntington's disease and Alzheimer's disease.

It is also being considered for anxiety and depression. But unlike THC, CBD doesn't get people high -- that's a key trait for many people who are wary of buzz-inducing drugs and for potential medical treatments for children. As for recreational users, the lack of CBD in marijuana means that many of the hundreds of strains they select from could in actuality be very similar chemically, according to LaFrate.

"There's a lot of homogeneity whether you're talking medical or retail level," he says. "One plant might have green leaves and another purple, and the absolute amount of cannabinoids might change, which relates to strength. But the ratio of THC to CBD to other cannabinoids isn't changing a whole lot." That means there might be little difference in how the varieties make you feel, even though some people claim one kind will make you mellow and another will make you alert, LaFrate explains.

As for contamination testing, although Colorado doesn't yet require it, some producers have voluntarily submitted samples to see what's in their products. LaFrate says the results have been surprising. His lab looks for both biological and chemical contaminants, such as pathogenic microbes and solvents.

"It's pretty startling just how dirty a lot of this stuff is," he says. "You'll see a marijuana bud that looks beautiful. And then we run it through a biological assay, and we see that it's covered in fungi."

The lab also finds varying levels of chemical contaminants such as butane, which is used to create marijuana extracts. Contamination isn't necessarily a cause for alarm, but it does signal a need to figure out what levels are safe.

"It's a natural product," LaFrate says. "There's going to be microbial growth on it no matter what you do. So the questions become: What's a safe threshold? And which contaminants do we need to be concerned about?"

In other words, legalizing marijuana has raised a lot of issues that still have to be hammered out. LaFrate, who has been involved with the policy side of Colorado's new marijuana market, as well as the laboratory side, says he expects regulations will continue to evolve as scientists, lawmakers and others learn more about the plant and its products.

A press conference on this topic will be held Monday, March 23, at 2 p.m. Mountain time in the Colorado Convention Center. Reporters may check-in at Room 104 in person, or watch live on YouTube To ask questions, sign in with a Google account.


The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 158,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact

Note to journalists: Please report that this research is being presented at a meeting of the American Chemical Society.

Follow us: Twitter | Facebook

State mandated testing of retail marijuana in Colorado

In 2012, Colorado voters approved Amendment 64 which legalized the sale of recreational marijuana to adults age 21 and over. Written into the amendment were provisions that require all products to be tested for cannabinoid potency and contaminants prior to sale. The Marijuana Enforcement Division (MED) within the State's Department of Revenue had been regulating medical marijuana for years and was tasked with setting rules for the mandatory testing program. This presentation will summarize marijuana testing rules in Colorado, methods used for testing and an overview of test results for recreational marijuana. The law requires every "batch" to be tested for several different chemical and biological entities and the rules are quite complex. Methods such as high performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (LCMS), microbial culture and real time polymerase chain reaction (PCR) are utilized in testing. The results obtained are both fascinating and shocking and offer a scientific glimpse at an industry in its infancy.

Michael Bernstein | EurekAlert!

More articles from Life Sciences:

nachricht Molecular doorstop could be key to new tuberculosis drugs
20.03.2018 | Rockefeller University

nachricht Modified biomaterials self-assemble on temperature cues
20.03.2018 | Duke University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

Physicists made crystal lattice from polaritons

20.03.2018 | Physics and Astronomy

Mars' oceans formed early, possibly aided by massive volcanic eruptions

20.03.2018 | Physics and Astronomy

Thawing permafrost produces more methane than expected

20.03.2018 | Earth Sciences

Science & Research
Overview of more VideoLinks >>>