Science has published another article by Bogdanove in the Sept. 30 issue that updates the scientific community on where the research has been since 2009 and where it is heading.
"In the past two years, an extraordinary number of things have happened in this field," said Bogdanove, a professor of plant pathology. "This is really pretty revolutionary."
Bogdanove's research published in 2009 uncovered how so-called TAL (Transcription Activator-like) effector proteins bind to different DNA locations, and how particular amino acids in each protein determine those locations -- called binding sites -- in a very straightforward way.
Knowing this, scientists are using the proteins to target and manipulate specific genes, something that was much more difficult to accomplish prior to this research.
That could lead to breakthroughs in understanding gene function and improving traits in livestock and plants, and even treating human genetic disorders, according to Bogdanove.
Bogdanove says in the two years since his and Moscou's work was published, nearly two dozen research papers have been published using this discovery.
"We are so excited about the potential of these proteins. Just in the past six months they have been used successfully in model organisms such as yeast, zebrafish, and C. elegans (a type of worm used to study development), and even in human stem cells. There is some really innovative stuff going on," he said.
Model organisms are used to understand particular biological functions.
Bogdanove collaborated on this Science article with Dan Voytas, a former member of the Iowa State University faculty and now director of the Center for Genome Engineering at the University of Minnesota.
Bogdanove cautions in the article that the power of the technologies based on TAL effectors raises legal, sociological and ethical questions about how their use should be regulated, but says that it may be just a matter of a few years before these proteins see real application in areas such as crop improvement and human medicine.
Adam Bogdanove | EurekAlert!
Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory
Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine