Science has published another article by Bogdanove in the Sept. 30 issue that updates the scientific community on where the research has been since 2009 and where it is heading.
"In the past two years, an extraordinary number of things have happened in this field," said Bogdanove, a professor of plant pathology. "This is really pretty revolutionary."
Bogdanove's research published in 2009 uncovered how so-called TAL (Transcription Activator-like) effector proteins bind to different DNA locations, and how particular amino acids in each protein determine those locations -- called binding sites -- in a very straightforward way.
Knowing this, scientists are using the proteins to target and manipulate specific genes, something that was much more difficult to accomplish prior to this research.
That could lead to breakthroughs in understanding gene function and improving traits in livestock and plants, and even treating human genetic disorders, according to Bogdanove.
Bogdanove says in the two years since his and Moscou's work was published, nearly two dozen research papers have been published using this discovery.
"We are so excited about the potential of these proteins. Just in the past six months they have been used successfully in model organisms such as yeast, zebrafish, and C. elegans (a type of worm used to study development), and even in human stem cells. There is some really innovative stuff going on," he said.
Model organisms are used to understand particular biological functions.
Bogdanove collaborated on this Science article with Dan Voytas, a former member of the Iowa State University faculty and now director of the Center for Genome Engineering at the University of Minnesota.
Bogdanove cautions in the article that the power of the technologies based on TAL effectors raises legal, sociological and ethical questions about how their use should be regulated, but says that it may be just a matter of a few years before these proteins see real application in areas such as crop improvement and human medicine.
Adam Bogdanove | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences