Lyric Bartholomay, assistant professor of entomology, along with colleagues from around the world, infected the common southern house mosquito (Culex quinquefasciatus) with various pathogens to see which mosquito genes are activated in response to the infection.
Bartholomay is the first author on the paper, "Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens," to be published in the Oct. 1 issue of the journal Science.
The southern house mosquito is the third of the three most important mosquito disease carriers to have its genome sequenced. The first was an African mosquito (Anopheles gambiae) that transmits malaria parasites. Malaria infects 250 to 500 million people each year and kills nearly one million people annually, mostly young children in sub-Saharan Africa. The second was a tropical mosquito (Aedes aegypti) that carries yellow and dengue fever viruses.
Bartholomay participated in cataloging the infection-response genes for Aedes aegypti in a manuscript published in 2007. She was chosen to be first author of the current Science paper because she has experience describing the immune responses in the northern house mosquito (Culex pipiens).
In the research, mosquitoes were infected with viruses, worms and bacteria. The genes of the mosquitoes were monitored to see which changed during the response to infection and therefore could ward off disease.
"What we're trying to do is broaden our understanding of infection response genes beyond those that we expect to be there," said Bartholomay.
"We took a two-pronged approach to understanding infection responses," she added. "First, we scoured the genome sequence looking for those immunity genes that the mosquitoes can use to respond to an infection. Then, we looked at what genes comprise broad spectrum and specific immune responses.
"We then took it one step further and compared the infection responses in Culex quinquefasciatus to similar infections in Aedes aegypti and Anopheles gambiae."
Bartholomay noted that the functions of many of the genes revealed in this analysis are still unknown, but as more is discovered about the functions of the genes, it could provide the first steps to controlling mosquito-borne diseases.
Bartholomay also worked with colleagues to analyze the mosquito's genome, as reported in a companion paper that will also be published in the current issue of Science.
Lyric Bartholomay | EurekAlert!
Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Physics and Astronomy
23.04.2018 | Physics and Astronomy
23.04.2018 | Trade Fair News