In 1928, chemists Otto Diels and Kurt Alder first documented diene synthesis, a chemical reaction important for synthesizing many polymers, alkaloids and steroids. Their work on this mechanism, which came to be known as the Diels–Alder reaction, won them the 1950 Nobel Prize in chemistry.
Since then, the iconic reaction has become the most commonly used and studied mechanism in organic chemistry. But what happens during the reaction has never been entirely clear.
Now, Kendall N. Houk, UCLA's Saul Winstein Professor of Organic Chemistry, and colleagues report exactly how the Diels–Alder reaction occurs. Their research was published last week in the early online edition of the journal Proceedings of the National Academy of Sciences and will be published in an upcoming print edition.
"We have examined the molecular dynamics of the Diels–Alder reaction, which has become the most important reaction in synthesis, in detail to understand how it happens," said Houk, who is a member of the California NanoSystems Institute at UCLA.
Houk and his colleagues created a number of simulations — he calls them short movies — of molecules coming together and reacting.
(Houk isn't the only one making movies about Diels–Alder. UCLA organic chemistry students in Professor Neil Garg's class have produced a series of amusing music videos in which they reference the reaction: Watch "Chemistry Jock" [reference at 2:08], "Hey There Neil Garg" [1:44] and "Payphone" [1:07].)
"The idea," Houk said, "is to understand how the reaction happens — not just that A goes to B and B goes to C, but to actually follow how the bonds are forming and how the atoms are moving as these things come together. Using the massive computing power we have now, we get a degree of resolution of the mechanism that was not really possible before. It took a lot of computer time, but as a result, we now have unprecedented insight into how this reaction occurs."
Organic chemists have argued about this for years: If two bonds form during a reaction, do they form at the same time, or does one form first and then the other?
"We find that for the simplest Diels–Alder cycloaddition, it takes only about five femtoseconds on average between the formation of the two bonds; we consider that as occurring simultaneously," Houk said. (A femtosecond is approximately one millionth of one billionth of a second.)
Houk's new PNAS paper is his first in the journal since being elected to the National Academy of Sciences in 2010. The same PNAS issue also features an interview with Houk, who is one of the most prolific chemists in the world and one of the world's leading physical organic chemists.
"We have studied many different classes of reactions and come up with various kinds of rules for understanding why things happen the way they do," Houk said in the interview.
He and his colleagues — who include David Baker at the University of Washington, Charles Doubleday at Columbia University and Kersey Black at Claremont McKenna College — use computational methods to better understand basic chemical reactions and to design proteins and enzymes to catalyze chemical reactions. The combination of computational design and molecular biology "leads to a catalyst for whatever reaction is needed, if we can get this all to work properly," Houk said.
Describing his research to predict the structure of novel proteins that could catalyze specific chemical reactions, he said, "The idea is to design a catalyst for any reaction that's important for whatever reason — an important drug or a commercial product, for example."
Designing proteins and enzymes is difficult, but it can be successful.
"We've beaten really enormous odds but have really just scratched the surface of what is possible," Houk said. "Future developments in theory and computing power should make this work much better."
Black and Doubleday are co-authors with Houk on the new PNAS article, along with Peng Liu, a postdoctoral scholar in Houk's laboratory, and Lai Xu, who earned her Ph.D. in Houk's lab and is currently a postdoctoral scholar at Texas Tech University. (Liu, who also conducted his Ph.D. research in Houk's lab, was awarded a UCLA Chancellor's postdoctoral award last month.)
Houk has pioneered the use of computer calculations and simulations to study organic chemistry and to predict chemical reactivity. His research group has made predictions of new phenomena that have been verified experimentally, and he has made critical contributions to our understanding of how enzymes are able to selectively catalyze reactions.
In 2008, his research group used computer methods to create "designer enzymes" and to predict structures of proteins that can catalyze reactions which do not occur naturally — a major milestone in computational chemistry and protein engineering. Designer enzymes are likely to have applications for defense against biological warfare by deactivating pathogenic biological agents, and for creating more effective medications, Houk said.
He and his colleagues are currently working on computational methods to predict catalysts for reactions that will have important applications in industry and in therapies for fighting disease.
"Our work is theoretical and computational but is always tied to real phenomena," Houk said. "We first try to understand what is happening and then try to make predictions that experimentalists can test. The goal of our research is to use computational methods to design the arrangement of groups inside a protein to cause any desired reaction to occur."
For more on Houk, visit his website at www.chem.ucla.edu/dept/Faculty/houk.html.
UCLA to celebrate life and legacy of late chemist Saul Winstein
On Oct. 6, UCLA will celebrate what would have been Saul Winstein's 100th birthday with a who's who of distinguished chemists. The event, which runs from 10 a.m. to 5 p.m. at the California NanoSystems Institute at UCLA, will be followed by a banquet at UCLA's Faculty Center.
Winstein, a professor at UCLA from 1941 until his death in 1969, was one of the leading physical organic chemists of the 1950s and '60s, employing the tools of physical chemistry to explore reactions in solution. In 1971, he was posthumously awarded the prestigious National Medal of Science. Winstein, his wife, Sylvia, who passed away this year, and their children all were undergraduates at UCLA.
Seventy-two students obtained their Ph.D. degrees under Winstein's supervision, and 86 postdoctoral fellows came from all parts of the world to collaborate with him.
"Saul Winstein was the most prominent physical organic chemist in the period when I began my career," said Houk, who holds the UCLA endowed chair named in honor of Winstein. "He is one of my heroes in chemistry. His specialty was understanding how reactions occur in solution. He developed many of the concepts that we use today. We now do computationally things that Saul Winstein used to do experimentally."
UCLA is California's largest university, with an enrollment of nearly 38,000 undergraduate and graduate students. The UCLA College of Letters and Science and the university's 11 professional schools feature renowned faculty and offer 337 degree programs and majors. UCLA is a national and international leader in the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. Six alumni and five faculty have been awarded the Nobel Prize.
For more news, visit the UCLA Newsroom and follow us on Twitter.
Stuart Wolpert | EurekAlert!
First time-lapse footage of cell activity during limb regeneration
25.10.2016 | eLife
Phenotype at the push of a button
25.10.2016 | Institut für Pflanzenbiochemie
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Power and Electrical Engineering
26.10.2016 | Awards Funding
26.10.2016 | Power and Electrical Engineering