Until now, scientists assumed that these two poles develop in all epithelial cells in the same manner - irrespective of whether they are located in the heart, in the retina, or in the nervous system. Now, Dr. Nana Bit-Avragim, Dr. Nicole Hellwig, and Dr. Salim Abdelilah-Seyfried have shown that, depending on the tissue, a different variation of a complex consisting of five core proteins is active and orientates the epithelial cells. The results of the MDC scientists have now been published in the Journal of Cell Science (2008, Vol. 121, pp. 2503-2510)*.
Scientists worldwide use zebrafish to study the development of vertebrates, the group to which humans also belong. Zebrafish are only a few centimeters long and their embryos are transparent, which is why researchers can observe every change under the microscope. In the early development of zebrafish, the heart is like a tube surrounded by a pump of epithelial cells.
The upper and lower sides of an epithelial cell are clearly different. The upper side, which forms a boundary between organs and either tissue fluid, hollow spaces, or the environment, has a different function than the lower side facing the connective tissue. Both poles of an epithelial cell are vital for the functioning of the heart and other organs.
*Divergent polarization mechanisms during vertebrate epithelial development mediated by the Crumbs complex protein Nagie oko
Nana Bit-Avragim1,2,*, Nicole Hellwig1,*, Franziska Rudolph1, Chantilly Munson3, Didier Y.S. Stainier3 and Salim Abdelilah-Seyfried1,?
3Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94143-2711, USABarbara Bachtler
Barbara Bachtler | idw
Scientists enlist engineered protein to battle the MERS virus
22.05.2017 | University of Toronto
Insight into enzyme's 3-D structure could cut biofuel costs
19.05.2017 | DOE/Los Alamos National Laboratory
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
22.05.2017 | Event News
17.05.2017 | Event News
16.05.2017 | Event News
22.05.2017 | Materials Sciences
22.05.2017 | Life Sciences
22.05.2017 | Physics and Astronomy