In case of an inflammation the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage.
A research group from the Department of Biomedicine at the University and the University Children’s Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation.
Innate lymphoid cells (ILC3s) with internalized antigens (red fluorescent dots).
Illustration: University of Basel, Department of Biomedicine
These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation. The study was recently published in the scientific journal PNAS.
Innate lymphoid cells (ILCs) are immune cells that regulate early immune responses against viruses, bacteria and parasites through the release of soluble factors. These cells can be classified into three subsets that each have various functions. Type 3 ILCs (ILC3s) are in addition essential for the development of lymphoid organs such as lymph nodes and for tissue repair.
ILC3s internalize antigen and induce T cell responses
The research group lead by Prof. Daniela Finke found that ILC3s take up antigens and present these via so-called MHC molecules on their surface. Specific T cells then recognize these antigen-loaded MHC molecules and induce immune responses. The importance of this interaction between ILC3s and T cells for the immune defense was shown in mice that were lacking the MHC molecules on their ILC3s. These animals had severely reduced T and B cell immune responses.
Inflammatory signals activate ILC3s
So far, scientists assumed that ILC3s decreased T cell responses because they were lacking certain additional receptors required for efficient T cell stimulation. The research group of Prof. Finke was able to show for the first time that these important costimulatory receptors are produced by ILC3s when they are activated through inflammatory signals such as the soluble factor IL-1β. Moreover, ILC3s then produce factors that promote T cell responses.
The results of the Basel research team open up new ways for improving immune responses after vaccination and for preventing harmful immune responses for example during chronic inflammation.
Nicole von Burg, Stéphane Chappaz, Anne Baerenwaldt, Edit Horvath, Somdeb Bose Dasgupta, Devika Ashok, Jean Pieters, Fabienne Tacchini-Cottier, Antonius Rolink, Hans Acha-Orbea, and Daniela Finke
Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses
PNAS; published online 18 August 2014 | doi: 10.1073/pnas.1406908111
Prof. Dr. Daniela Finke, University of Basel, Department Biomedicine, and University Children’s Hospital Basel, phone: +41 61 695 30 71, email: firstname.lastname@example.org
Reto Caluori | Universität Basel
Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Physics and Astronomy
08.12.2016 | Health and Medicine
08.12.2016 | Life Sciences