This study uses a novel class of experimental drugs to halt a process that helps AML cells develop and survive.
The findings show that the agent is promising and should be considered for clinical trials testing.A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia, according to a study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
Reduce the amount of CRM1 protein in the nucleus and increase the amount of tumor-suppressor protein such as p53 and NPM1 in AML cells.
Strongly down-regulate FLT3 and KIT, oncogenes that are commonly overexpressed in AML.
Increase survival in a leukemia animal model, with treated mice living an average of 39 days versus 27 days for untreated animals.
Darrell E. Ward | EurekAlert!
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