Like mother, like daughter; like father, like son. Evolutionary biologists at the universities in Bielefeld and Uppsala (Sweden) have now shown that this proverb also applies to inheriting a long life – at least for fruit flies (Drosophila).
The research team found that the descendants of these insects mostly inherit their lifespan from their own sex: male descendants will very probably live about as long as their fathers; female descendants, about as long as their mothers. The scientists are publishing their findings on Thursday 12 September in the renowned journal „American Naturalist”.
The new study by the German–Swedish research team has turned a previous assumption by biologists and physicians upside down: up to now, they had thought that the genetic risk of a disease was equally strong in both female and male descendants.
The study proceeded from the assumption that the average life expectancy of women and men differs –this may be for genetic reasons but also due to different lifestyles. The German–Swedish research team wanted to find out how far this sex difference in the lifespan depends on the genetic make-up.
To carry out their experiments, the researchers intervened in the heredity of fruit flies by cross-breeding them with special fly mutants. This enabled them to breed 50 hemi-clones; that is, groups of individuals in whom one-half of the genetic make-up is absolutely identical, whereas the other half is completely unrelated. From each hemi-clone, the researchers determined the lifespan of 400 females and 400 males. ‘What’s special about this approach is that it enables us to measure the influence of this 50 per cent identical genetic make-up in both sexes’, says Dr. Holger Schielzeth from the Faculty of Biology – one of the authors of the study.
The authors then used the data from the hemi-cloned fruit flies to read off how similar the individuals in a hemi-clone are and how far females and males from one hemi-clone share the same lifespan. Results showed that the lifespan was very similar within sexes, whereas the calculated relation between sexes was only slight. Hence, Methuselah genes in the father exert only a limited influence on female descendants – at least in fruit flies. Vice versa, particularly long-lived females do not necessarily have long-lived brothers, fathers, or sons. Approximately three-quarters of the genetic components of life expectation are effective only within the same sex.
The researchers conclude that the risk of a fatal hereditary disease is passed on above all within the same sex. ‘Gene variants that could be problematic for one sex seem to have only a comparatively low influence on the life expectation of the other sex’, says Holger Schielzeth. In principle, this finding could also generalize to human beings, because human life expectancy is also hereditary. According to Schielzeth, this sex-specific heredity may also be relevant for medicine, and that therapies should pay more attention to sex-specific risks.Original publication:
Ingo Lohuis | idw
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences