RUB-Researchers from the Chair for Biophysics have developed a new method for the detailed study of the interaction between pharmaceuticals and their target proteins.
The pharmaceutical industry has already taken notice of the new infrared spectroscopy technique; the method is supposed to be implemented to investigate pharmacological agent-protein interactions in the EU project K4DD, which is supported by various major European pharmaceutical companies. “We now have a tool in our hands with which we can research the dynamics of pharmacologically interesting proteins in atomic detail,” Prof. Dr. Klaus Gerwert said.
“We want to undertake a targeted screening of substance libraries to look for potential pharmacological agents.” PD Dr. Carsten Kötting added that “with our technique future pharmaceuticals can be more closely tailored to illness-causing proteins, which can noticeably reduce the negative side effects of these drugs.” They described the new method together with Dr. Jörn Güldenhaupt and Philipp Pinkerneil in the scientific journal “ChemPhysChem,” which dedicated its cover story to this topic.
Funding for the project came from the Protein Research Department at the RUB, from the state of NRW in the framework of the Center for Vibrational Microscopy (CVM) and from the SFB 642, “GTP and ATP Dependent Membrane Processes,” whose speaker is Prof. Gerwert.
Further InformationProf. Dr. Klaus Gerwert, Chair for Biophysics, Faculty for Biology and Biotechnology at the Ruhr-Universität, 44780 Bochum, Germany, Phone: +49/234/32-24461
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Dr. Josef König | idw
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