Being able to predict the different regions in a new and unannotated genome is one of the biggest challenges facing biologists today.
Now researchers at the Indian Institute of Technology in Delhi have used techniques from information theory to identify DNA introns and exons an order of magnitude faster than previously developed methods.
The researchers were able to achieve this breakthrough in speed by looking at how electrical charges are distributed in the DNA nucleotide bases. This distribution, known as the dipole moment, affects the stability, solubility, melting point, and other physio-chemical properties of DNA that have been used in the past to distinguish exons and introns.
The research team computed the "superinformation," or a measure of the randomness of the randomness, for the angles of the dipole moments in a sequence of nucleotides. For both double- and single-strand forms of DNA, the superinformation of the introns was significantly higher than for the exons.
Scientists can use information about the coding and noncoding regions of DNA to better understand the human genome, potentially helping to predict how cancer and other diseases linked to DNA develop.
Article: "Dipole-entropy-based techniques for segmentation of introns and exons in DNA," is published in Applied Physics Letters.
Authors: Nithya Ramakrishnan (1) and Ranjan Bose (1)
(1) Indian Institute of Technology, Delhi, India
Catherine Meyers | EurekAlert!
Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main
Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
24.05.2018 | Ecology, The Environment and Conservation
24.05.2018 | Medical Engineering
24.05.2018 | Physics and Astronomy