Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Infant Estrogen Levels Tracked Through Diaper Research

17.11.2010
With the help of babies and more than 5,000 of their diapers, Emory University researchers have developed an accurate, noninvasive method to determine estrogen levels in infants.

The method, previously used in nonhuman primates, will allow researchers to learn more about the association between estrogen levels in human infants and their long-term reproductive development as well as the development of sex-specific behaviors, such as toy preference or cognitive differences.

What’s more, the method will also allow researchers to look at how early disruption of the endocrine system affects long-term maturation, a growing concern among researchers and physicians.

Surprisingly little is known about hormone levels during human infancy. Previous human research has focused on the measurement of hormones in blood, urine and saliva. The new data are the result of using fecal samples collected from cotton diapers. With this novel approach, the researchers successfully measured the fecal levels of estradiol, a type of estrogen.

The well-known importance of estradiol’s role in postnatal development of the body, brain and behavior has in recent years raised specific concerns about how exogenous estrogens, or environmental estrogens, such as those found in soy, fruits and vegetables, plastics and common household items, affect lifelong health.

“The development of robust, noninvasive methods to measure these hormones in infants allows us to further investigate the association between postnatal hormone production and the development of sex-specific biology and behavior,” says Michelle Lampl, PhD, MD, Emory University Samuel Candler Dobbs professor of anthropology, and senior author of a paper in Frontiers in Systems Biology describing the new method. The study, conducted by researchers at Emory, the University of North Carolina at Chapel Hill and the University of Virginia Health System, Charlottesville, appears online and in the current issue of Frontiers in Systems Biology.

“The development of an assay to measure estrogen from diapers might initially strike one as unnecessary or strange, but the need is real,” says Sara Berga, MD, James Robert McCord professor and chairman, Department of Gynecology and Obstetrics, Emory University School of Medicine.

“We understand very little about the hormonal dynamics that occur during early development precisely because we lack a reliable way to track hormones in neonates and very young children. Having a way to track this critical hormone that influences behavior and the development of many important tissues, including the brain, will allow us to understand normal. This really is a great leap forward, and the investigators should be congratulated on this advance.”

The paper’s lead author is Amanda L. Thompson, PhD, who conducted the research at Emory and is now assistant professor of anthropology at the University of North Carolina, Chapel Hill. Other authors are corresponding author Michael L. Johnson, PhD, University of Virginia Health System, and Patricia L. Whitten, Emory University.

Because of the ethical and practical difficulties of repeatedly taking blood samples from healthy infants, little data are currently available for charting the developmental pathways of estradiol. As such, existing data describe only the range of variability in hormonal levels--not developmental trends or what that variability might mean when it comes to individual physical and behavioral development.

The study included 32 infants, 15 male and 17 female, aged 7 days to 15 months. The infants’ parents retained soiled diapers after each diaper change during a 24-hour period. Bagged diapers were collected and then frozen and stored at - 80°C and analyzed 24 hours to 12 months after collection. In preparation for analysis, diapers were thawed overnight at 2 to 8°C.

Previous studies in primates have shown a close parallel between fecal levels of estradiol and serum values. Likewise, a comparison of fecal steroid levels between the study infants and previous studies of human adults shows an overlapping pattern, a pattern that is also seen in infant serum when compared with adult serum.

“These observations are the first report of human infant fecal estradiol levels and they provide a new tool for investigating early human development", says Lampl. “Because infant diapers are plentiful, fecal samples can be collected frequently and over a long period of time. Future longitudinal studies will allow the association between fecal levels of steroids and physiological measures to be assessed, and expand our understanding independent of serum measures.”

At Emory, Lampl also serves as associate director of the Emory/Georgia Tech Predictive Health Institute.

Lampl's research centers on human growth spurts, with a focus on fetal and infant stages of life. Her current work investigates the relationship between nutrition, immunological and hormonal networks that interact with behavior to influence developmental processes.

Writer: Robin Tricoles

The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service. Its components include the Emory University School of Medicine, Nell Hodgson Woodruff School of Nursing, and Rollins School of Public Health; Yerkes National Primate Research Center; Winship Cancer Institute of Emory University; and Emory Healthcare, the largest, most comprehensive health system in Georgia. Emory Healthcare includes: The Emory Clinic, Emory-Children's Center, Emory University Hospital, Emory University Hospital Midtown, Wesley Woods Center, and Emory University Orthopaedics & Spine Hospital. The Woodruff Health Sciences Center has a $2.5 billion budget, 17,600 employees, 2,500 full-time and 1,500 affiliated faculty, 4,700 students and trainees, and a $5.7 billion economic impact on metro Atlanta.

Holly Korschun | EurekAlert!
Further information:
http://emoryhealthsciences.org

More articles from Life Sciences:

nachricht Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University

nachricht How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>