To understand how different materials are taken up and what happens within the cells can for example facilitate the development of new vaccines.
"The immune system is a large and important part of ourselves and the dendritic cells are important for the activation of this system", Linda Andersson says.
"One task of the immune system is to protect the body from infections. The dendritic cells have an unique ability to obtain samples from its environment and treat the material, in process called endocytosis. In my study I have explored how dendritic cells recognise and capture particles. "
To study the endocytosing ability of dendritic cells Linda Andersson has used zeolite particles and through them different biomolecules are transported into the cell. With the help of zeolites you can follow different paths and study what happens within the cell.
"The result shows that zeolites are an useful tool for studying endocytosis and that there are differences between various dendritic cells," Linda Andersson says.
A method is developed for studying the early activities of the endocytosing mechanism within the cells. From this you can go further and study other processes and other types of cells.
Zeolites belong to a group of silica particles which easily can adsorb different types of molecules, for example antibodies and other proteins. The type of molecule and the charge and amount of molecules affects the endocytosing ability of the cells.
Dendritic cells are found in different parts of the body, for example skin, mucous, spleen and circulating in the blood. Linda Andersson has chosen to study the cells in the blood. In her study dendritic cells from the blood are compared with dendritic cells produced in vitro, that is from a culture in an artificial environment. Dendritic cells are not so common in the blood. Through in vitro-culture you can easily produce many dendritic cells.
"The differences in the early events of the endocytosing mechanism between these two types of cells were considerable", Linda Andersson says.
This is important to point out, since in vitro-cells are among other things considered in the development of new vaccines. The blood cells are better at taking up particles while the in vitro-cells are better at taking up proteins and soluble molecules.
The thesis by Linda Andersson contributes to an increased understanding of how the important dendritic cells work.
"I hope that the method developed in my study can be used to produce more knowledge about the different paths of the endocytosed material and how the dendritic cells recognise and capture the bodies own material and foreign harmful material", Linda Andersson says.
For more information contact Linda Andersson, tel +46 40 665 79 57, +46 704 94 33 31, e-mail: firstname.lastname@example.org
Pressofficer Hanna Holm; +46-40 665 70 22; Hanna.Holm@mah.se
Hanna Holm | idw
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences