During their study, the researchers investigated over 500,000 positions in the human genome, and found a gene variant which occurs clearly more frequently in bald men than in control persons.
The results are to be published in the November issue of the journal “Nature Genetics” (online publication on October 12th 2008 18:00 London time, doi: 10.1038/ng.228). In 2005, these scientists had already characterized the first hair-loss gene inherited through the maternal line, which explained why hair-loss in men often reflects that of their maternal grandfathers. This newly discovered gene, on the other hand, may now account for the similarity in cranial hair growth between father and son.
The researchers had concentrated their attention on the genomes of just under 300 men suffering from marked hair loss, investigating for this purpose over 500,000 variable sites in the genomes of their test subjects. Two positions frequently displayed a clear correspondence with baldness in these men – a clear indication that the genes located at those points were involved in hair-loss. “In one of these conspicuous regions lies the gene for the androgen receptor“, Dr. Axel Hillmer of the Life&Brain Forschungszentrum (research centre) in Bonn states. ”We had already learnt from an earlier study that this receptor was linked to hair loss. However, the other region was new to us“.
This is only the second region of the genome that can definitely be associated with premature hair-loss. “We are now trying to discover the role played by this genomic region in hair-growth”, says Dr. Felix Brockschmidt of Bonn University. “Only then will we know whether we on the right track for new forms of therapy for male hair-loss”.
The study was conducted by the research teams headed by Professor Dr. Markus Nöthen (Bonn University´s Institute of Human Genetics and Life & Brain-Center) and Privatdozent Dr. Roland Kruse (Department of Dermatology, University Clinic Düsseldorf). Over a period of years, the scientists had collected blood samples from affected males all over Germany. As part of their study, they have been able to confirm their findings through additional sufferers in Australia. The Australian research team is headed by Nicholas Martin (Queensland Institute of Medical Research, Brisbane).
If the father is bald, the son is also at risk
The results reveal that more than one gene is involved in the development of male hair-loss. These results also throw interesting light on the inheritance of baldness in that hitherto the only known risk gene for the androgen receptor lay on the X-chromosome, and was thus inherited from the mother – which accounts for the fact that in the case of hair-loss men often take after their maternal grandfathers. However, the newly discovered gene lies on chromosome 20, and can be inherited from both the mother and the father. “This helps to provide an explanation for the similarity between father and son“, declares Professor Nöthen.
The scientists suspect that other genes are also involved in premature hair-loss, and they are now looking for new volunteers to help with this research. “We are looking for men under 40 years of age who have advanced hair-loss”, says Privatdozent Dr. Kruse. “And we are also seeking men over 60 with a full head of hair as controls. All participants will receive expense allowances.“ Further information may be obtained from PD Dr. Roland Kruse, Dr. Sandra Hanneken or Dr. Sibylle Eigelshoven, Universitäts-Hautklinik Düsseldorf, telephone 0211/8116360 or e-mail Roland.Kruse@med.uni-duesseldorf.de.
Prof. Dr. Markus M. Nöthen | alfa
Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth
01.03.2017 | Hochschule für Angewandte Wissenschaften Hamburg
Researchers Imitate Molecular Crowding in Cells
01.03.2017 | Universität Basel
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
01.03.2017 | Health and Medicine
01.03.2017 | Physics and Astronomy
01.03.2017 | Life Sciences