Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Immune system fighters speak in patterns of proteins, prefer squishy partners

29.10.2012
When talking to the key immune system fighters known as T-cells, it helps to speak their language.

Now researchers from Columbia University in New York, N.Y., and the University of Pennsylvania in Philadelphia have discovered two new conditions for communication that may help scientists one day harness the power of T-cells to fight diseases such as cancer. The team will present its findings at the AVS 59th International Symposium and Exhibition, held Oct. 28 – Nov. 2 in Tampa, Fla.

T-cells flow freely throughout the body and communicate with their partner T-cells, in part, through signals expressed in proteins on their surfaces. But unlike other freely circulating cells, T-cells are a bit more touchy-feely. "They stick to each other; they kind of crawl on each other," says lead researcher Lance Kam, a biomedical engineer at Columbia University. The cells spread onto each other; they put new proteins into the interface between them. And these proteins at the interface, Kam continues, "organize into some really beautiful patterns." One arrangement is shaped like a bulls-eye.

Kam's team wanted to find out whether the spacing of the proteins in these cellular tete-a-tetes plays a part in the communication process, and whether the squishiness or rigidity of the cells has any effect on the conversation. Using a custom-made artificial cell, they tested whether the real T-cells "liked" certain configurations of proteins on its surface. Not only did the team find that the spacing of the signaling proteins mattered for the proper activation of T-cells, but the rigidity of the surface mattered as well. Mouse cells – like most cells – preferred a more rigid surface, but human T-cells liked squishier partners.

Knowing that these two conditions figure into T-cell activation may help drug researchers design optimal T-cell habitats in which to grow huge T-cell armies to fight cancers and other diseases. While this reality is several years away, the two new findings that the team presents will help advance the harnessing of T-cells for immunotherapy. This type of cancer treatment involves removing a patient's T-cells, expanding their numbers, training them to recognize cancer cells, and re-injecting this fortified army back into the patient. Understanding what kind of partner the T-cells prefer could help to make this process more effective.

"We think that by learning more about the natural interface, the natural signals that activate the cells, we can get better control over the cell expansion process," Kam says, resulting in larger production of high-quality T-cells that can fight cancer.

MORE INFORMATION ABOUT THE AVS 59th INTERNATIONAL SYMPOSIUM & EXHIBITION

The Tampa Convention Center is located along the Riverwalk in the heart of downtown Tampa at 333 S. Franklin St., Tampa, Florida, 33602.

USEFUL LINKS:

Main meeting website: http://www2.avs.org/symposium/AVS59/pages/greetings.html

Technical Program: http://www.avssymposium.org/

Housing and Travel Information: http://www2.avs.org/symposium/AVS59/pages/housing_travel.html

PRESS REGISTRATION

The AVS Pressroom will be located in the Tampa Convention Center. Your complimentary media badge will allow you to utilize the pressroom to write, interview, collect new product releases, review material, or just relax. The media badge will also admit you, free of charge, into the exhibit area, lectures, and technical sessions, as well as the Welcome Mixer on Monday evening and the Awards Ceremony and Reception on Wednesday night. Pressroom hours are Monday-Thursday, 8-5 p.m.

To register, please contact:

Della Miller, AVS
E-mail: della@avs.org
This news release was prepared for AVS by the American Institute of Physics (AIP).

ABOUT AVS

Founded in 1953, AVS is a not-for-profit professional society that promotes communication between academia, government laboratories, and industry for the purpose of sharing research and development findings over a broad range of technologically relevant topics. Its symposia and journals provide an important forum for the dissemination of information in many areas of science and technology, enabling a critical gateway for the rapid insertion of scientific breakthroughs into manufacturing realities.

Catherine Meyers | EurekAlert!
Further information:
http://www.aip.org

Further reports about: Immune cell activation T-cell proteins signaling protein

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>