Our immune system plays an essential role in protecting us from diseases, but how does it do this exactly? Dutch biologist Suzanne van Helden discovered that before dendritic cells move to the lymph nodes they lose their sticky feet.
This helps them to move much faster. Immature dendritic cells patrol the tissues in search of antigens. After exposure to such antigens they undergo a rigorous maturation process. During this maturation the dendritic cells migrate to the lymph nodes to activate T cells. Suzanne van Helden studied the adhesion and migration of both immature and mature dendritic cells.Dendritic cell as a general
Van Helden not only demonstrated that dendritic cells lose their podosomes very quickly during maturation but she also identified the substances that are responsible for their disappearance. The presence of prostaglandin E2 is indispensable for this disassembly. In addition, it appears that dendritic cells lose their podosomes after interaction with certain bacteria. What is striking is that only gram-negative bacteria lead to podosome loss. Gram-positive bacteria do not have this effect. Van Helden concludes that dendritic cells can apparently distinguish between different pathogens.Dendritic cells in action
Van Helden carried out her research within a group of scientists that study the function of dendritic cells in different ways. The research comprises not only fundamental research, as in Van Helden's case, but also preclinical and clinical trials. The research was made possible by a grant from NWO. Spinoza Prize winner Carl Figdor supervised Van Helden during her research.
Kim van den Wijngaard | alfa
Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München
Second research flight into zero gravity
21.10.2016 | Universität Zürich
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences