NK cells are our first line of defence against dangerous cells, such as tumour cells and cells infected with bacteria and viruses. Researchers are keen to understand how NK cells work because they help the body to fight infection and stop tumours from growing. It is thought that it may ultimately be possible to design drugs that harness the cells' ability to fight disease.
Prior to today's study, it was already known that NK cells can kill their target cells by attaching onto them, forming a connection called an immune synapse, which they use to pass toxic molecules into their target. However, sometimes the target cells move away from the NK cells to escape being killed.
Today's study, which was funded by the Medical Research Council and the Association pour la recherche sur le cancer (ARC), shows that NK cells can keep hold of their target cells by snaring them with a bungee-like tube, called a membrane nanotube. The cells then either recoil the target cells back into direct contact to be killed, or kill them from a distance.
Professor Daniel Davis, corresponding author of the study from the Division of Cell & Molecular Biology at Imperial College London said: "Natural Killer cells are cells that are really good at killing tumours and virus-infected cells. It was thought they kill these diseased cells only by sticking to them tightly for several minutes. These new movies show that in fact they also tether cells with long membrane connections and can pull diseased cells back into contact. We think they may also use these nanotubes to kill them from a distance.
"The movies show the process vividly but the next step is difficult because we have to know where and when these processes are important in your body, and the technology to see such thin nanotubes in the body hasn't been invented yet! It's a very new research area and we need to learn how the process works precisely so that we can then think about ways to design drugs that help immune cells kill," added Professor Davis.
Their next step will be to find out exactly how the bungee tubes help immune cells kill their target cells. The researchers hope that a better understanding of the process may help others in the future to develop drugs to improve the function of NK cells.
The researchers looked at the membrane nanotubes by staining cells with a dye that reveals membranes in microscope images. They found membrane nanotubes connecting NK cells with other NK cells, tumour cells, cells infected with viruses and cancer cells.
The researchers took video footage of the cells, showing the target cells moving away and being pulled back towards the NK cells. When a target cell moves away from an NK cell, it normally moves 'head' first, at around eight micrometres per minute. However, today's research shows that when the NK cell pulls its target cell back using the nanotube bungee it moves much faster, at around 14 micrometres per minute, and the cell is pulled backwards.
Membrane nanotubes increase an NK cell's chance of killing its target cell from a distance dramatically. In today's study, NK cells killed their target cells from a distance in 12 out of 16 cases (75 per cent) if they were connected by a membrane nanotube, compared to four out of 18 (25 per cent) if the nanotube was cut.For further information please contact:
1. "Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells" PNAS, Monday 8 March 2010.
Corresponding author: Professor Daniel Davis, Imperial College London (For a full list of authors, please see paper) You can download a proof of the paper here: https://fileexchange.imperial.ac.uk/files/7849478b81d/NKBungee_proof.pdf
2. You can download images and videos of NK cells using membrane nanotubes to harness their target cells here:
Videos (credit PNAS): https://fileexchange.imperial.ac.uk/files/85d63e72680/NKBungee_movies.zip
3. About Imperial College London
Consistently rated amongst the world's best universities, Imperial College London is a science-based institution with a reputation for excellence in teaching and research that attracts 14,000 students and 6,000 staff of the highest international quality.
Innovative research at the College explores the interface between science, medicine, engineering and business, delivering practical solutions that improve quality of life and the environment - underpinned by a dynamic enterprise culture.
Since its foundation in 1907, Imperial's contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics. This commitment to the application of research for the benefit of all continues today, with current focuses including interdisciplinary collaborations to improve health in the UK and globally, tackle climate change and develop clean and sustainable sources of energy.
4. For almost 100 years the Medical Research Council has improved the health of people in the UK and around the world by supporting the highest quality science. The MRC invests in world-class scientists. It has produced 29 Nobel Prize winners and sustains a flourishing environment for internationally recognised research. The MRC focuses on making an impact and provides the financial muscle and scientific expertise behind medical breakthroughs, including one of the first antibiotics penicillin, the structure of DNA and the lethal link between smoking and cancer. Today MRC funded scientists tackle research into the major health challenges of the 21st century. www.mrc.ac.uk
Lucy Goodchild | EurekAlert!
Cloud Formation: How Feldspar Acts as Ice Nucleus
09.12.2016 | Karlsruher Institut für Technologie
Closing the carbon loop
08.12.2016 | University of Pittsburgh
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
08.12.2016 | Life Sciences
08.12.2016 | Physics and Astronomy
08.12.2016 | Materials Sciences