Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Two-in-One Imaging Agents

15.03.2012
MRI systems with high relaxivities and long luminescence lifetimes also suitable for time-gated fluorescence imaging

Accurate visualization of living systems is key to the correct diagnosis and effective treatment of many diseases, as well as an improved understanding of biological processes. Magnetic resonance imaging (MRI) is a popular non-invasive visualization technique, which requires a possibly toxic contrast agent in the target tissue.

Researchers have recently sought to combine MRI with confocal imaging, one of the most widely used imaging techniques in biology. For this combination to be effective, multimodal imaging agents that can function as MRI contrast agents and luminescent probes are required. Valérie C. Pierre and co-workers at the University of Minnesota report on improved magnetoluminescent systems in the European Journal of Inorganic Chemistry.

Such magnetoluminescent imaging agents consist of three components: a luminescent probe, a contrast agent, and a linker to combine the two. The use of lanthanide complexes as luminescent probes has the advantage of affording long luminescence lifetimes, which makes the system suitable for use in time-gated luminescence spectroscopy. Enhancing the absorption of the lanthanide terbium with a phenanthridine antenna provided an ideal luminescent probe. Magnetic iron oxide nanoparticles, known for their superior longitudinal and especially transverse relaxivities, were employed as the contrast agent, and a polyethylene glycol (PEG) linker was used to coat the luminescent probes onto the magnetic nanoparticles.

In addition to a precise luminescent probe and a contrast agent with excellent relaxivities, these systems are not cytotoxic, as, for example, systems held together by silica matrices. Moreover, the PEG coating is not as thick and is more water-permeable, which results in considerably improved cellular uptake and higher relaxivity.

About the Author
The research group of Professor Valérie C. Pierre at the Department of Chemistry, University of Minnesota, focuses on the role of metal ions in biological systems, especially in the design of biological and medical probes by using the techniques of synthetic and analytical chemistry.
Author: Valérie C. Pierre, University of Minnesota, Minneapolis (USA), http://www.chem.umn.edu/directory/faculty.lasso?serial=2843
Title: Magnetoluminescent Agents for Dual MRI and Time-Gated Fluorescence Imaging

European Journal of Inorganic Chemistry, Permalink to the article: http://dx.doi.org/10.1002/ejic.201200045

Valérie C. Pierre | Wiley-VCH
Further information:
http://www.wiley-vch.de
http://www.chem.umn.edu/directory/faculty.lasso?serial=2843

More articles from Life Sciences:

nachricht Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg

nachricht Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>